Immunometabolomics (PI: Dr. Agustin Lahoz, Dr. Juan Carlos García Cañaveras, IIS La Fe, Individual) 2017
Title: CD8+ T cell metabolism in anti-tumor response.
Objective: The main objective of the Immunometabolomics project is to understand metabolism in CD8+ T cells, during active effector T cell development and exhaustion, using approaches that go beyond current research which have been mostly focused on glucose/energy metabolism thus disregarding the relevance of anabolic and redox reactions that are crucial in correct cellular function and proliferation.
CrowdHEALTH (PI: Dr. Bernardo Valdivieso, IIS La Fe, Participant) 2017
Title: Collective wisdom driving public health policies.
Objective: CrowdHEALTH will introduce a new paradigm of Holistic Health Records (HHRs) that include all health determinants. HHRs will be transformed into Social HHRs communities capturing the clinical, social and human context of the population segmentation and as a result the collective knowledge for different factors depending on the communities formulation criteria (e.g. demographics, diseases, lifestyle choices, nutrition, etc).
HARMONY (PI: Dr. Guillermo Sanz, IIS La Fe, Co-Chair) 2016
Title: Healthcare Alliance for Resourceful Medicines Offensive against Neoplasms in HematologY.
Objective: HARMONY is a European Network of Excellence that captures, integrates, analyzes and harmonizes Big Data from high-quality multidisciplinary sources for the purpose of acquiring valuable knowledge across the spectrum of hematologic malignancies (HMs). HARMONY will focus on HM disease areas with a high unmet need: multiple myeloma (MM), acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), non-Hodgkin lymphomas (NHL), myelodysplastic syndromes (MDS), and pediatric HMs.
Cardio-respiratory responses in dolphins (PI: Dr. Andreas Fahlman, IIS La Fe, Individual) 2016
Title: Cardiorespiratory physiology in the bottlenose dolphin before, during, and after breath-holding and restraint.
Call: Office of Naval Research Contracts&Grants 2015.
Objective: The proposed work is intended to evaluate cardiorespiratory (heart rate, stroke volume, systemic and pulmoarterial pressures, respiratory flow and expired gas composition) function in a small cetacean, the bottlenose dolphin, at rest, during apnea, during recovery from apnea and during and following a stressful situation. In addition, we will use these data to extract medical biomarkers from animals that are adapted to a range of extreme physiological challenges (e.g. hypoxia, ischemia/reperfusion, atelectasis). These biomarkers may provide valuable information for human clinical medicine.
Hibbs (PI: Dr. Máximo Vento, IIS La Fe, Consultant) 2016
Title: Association between Intermittent Hypoxia and Later Respiratory Morbidity.
Objective: Longer term respiratory morbidity remains a major consequence of preterm birth. The hypotheses will be in Aims 1 and 2 that IH episodes at one week and one month of life are significantly associated with prolonged duration of hospitalization and respiratory support, as well as a high incidence of wheezing disorders by six months adjusted age. In Aim 3 that low serotonin levels are associated with a high incidence of IH and a prolonged recovery of respiratory effort after onset of desaturation. Finally, in Aim 4 a temporal relationship between IH episodes and markers of oxidative stress determined by urine and blood samples.
ALBINO (PI: Dr. Máximo Vento, IIS La Fe, Participant) 2015
Title: Effect of allopurinol in addition to hypothermia for hypoxic-ischemic brain injury on neurocognitive outcome.
Objective: This project aims to evaluate the efficacy and safety of allopurinol administered immediately after birth to near-term infants with HIE in addition to hypothermic treatment. The project will also provide information on the effect of hypothermia on pharmacokinetics of drugs with a similar metabolism as allopurinol in neonates, and develop and validate biomarkers for neonatal brain injury using advanced magnetic resonance imaging, biochemistry, and electroencephalogramms, which will then be available for future studies testing neuroprotective interventions.
COBIOPHAD (PI: Dr. Dolores Hernández F. de Rojas, IIS La Fe, Participant) 2015
Title: Compact biophotonic platform for drug allergy diagnosis.
Objective: COBIOPHAD aims the development of an innovative in vitro diagnostic (IVD) device for diagnosis of IgE-mediated drug allergies by building an integrated biophotonic system based on compact disc technology. For that, key enabling technologies will be integrated in order to achieve high sensitive (<0.1 kUA/L), selective (>98%), multiplexed (10 BLCs), rapid (30 min), and low-cost (2.4 €/allergen) drug allergy test. The solution involves an advanced approach to the diagnosis and management of drug allergy with the aim to ameliorate patient safety.
TORPIDO-2 (PI: Dr. Máximo Vento, IIS La Fe, Participant) 2015
Title: Targeted Oxygenation in the Resuscitation of Premature Infants: Effects on Developmental Outcome – the TORPIDO2 Study.
Call: National Health and Medical Research Council (NHMRC), 2015.
Objective: The TORPIDO 2 study is a pragmatic, randomised controlled trial (RCT) in infants between 23 weeks and 28 weeks 6 days gestation which aims to test one primary and two secondary hypotheses; that, compared with starting resuscitation with 60% oxygen and a targeted oxygen saturation (SpO2) strategy, starting resuscitation with room air (21% oxygen) and the same targeted SpO2 strategy will improve the survival without major disability at 2 years corrected for gestation.
WiBEC (PI: Dr. Vicente Pons, IIS La Fe, Participant) 2015
Title: Wireless in-body environment communications.
Objective: The main objective is to provide high quality and innovative doctoral training to develop the wireless technologies for novel implantable devices that will contribute to the improvement in quality and efficacy of healthcare.
Title: EUTOXRISK21. An Integrated EUropean ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century.
Objective: The project will focus on repeated dose systemic toxicity (liver, kidney, lung and nervous system) as well as developmental/reproduction toxicity. EUToxRisk21 extensively integrates the adverse outcome pathway (AOP)-based toxicity testing concept, with advanced technologies, including high throughput transcriptomics, RNA interference, and high throughput microscopy, providing quantitative and mechanistic underpinning of AOPs and key events (KE). The project combines in silico tools and in vitro assays by computational modelling approaches to provide quantitative data on the activation of KE of AOP. This information, together with detailed toxicokinetics data, and in vitro-in vivo extrapolation algorithms forms the basis for improved hazard and risk assessment.
HERO Research Grant (PI: Dr. Santiago Bonanad, IIS La Fe, Participant) 2015
Title: Cognitive - behavioural intervention program to improve adherence to prophylaxis and emotional state of patients with haemophilia.
Call: HERO (Haemophilia Experiences, Results and Opportunities) 2014.
Objective: The aim of this project is to present and evaluate the effectiveness of a psychological intervention program developed in order to improve adherence to prophilaxys in adults patients with severe hemophilia.
The Gerber Foundation (PI: Dr. Máximo Vento, IIS La Fe, Participant) 2015
Title: Efficacy of oro-pharyngeal mother’s milk: late-onset sepsis in LBW infants.
Call: The Gerber Foundation Grants 2014.
Objective: The aim of this project is to compare the effects of oropharyngeal administration of mother’s milk with buccal swabbing, to a placebo, for enhancing antioxidant defense maturation, or reducing pro-oxidant status in ELBW infants.
MDS-RIGHT (PI: Dr. Guillermo Sanz, IIS La Fe, Participant) 2015
Title: Providing the right care to the right patient with MyeloDysplastic Syndrome at the right time.
Call: Horizon 2020, H2020- PHC-17-2014.
Objective: The main objective of MDS-RIGHT is to develop more effective and safe interventions for elderly patients with anemia and/or low-risk of Myelodysplastic Syndrome (MDS) by analyzing the European database EUMDS (European MDS Registry).
Emp-H (PI: Dr. Bernardo Valdivieso, IIS La Fe, Participant) 2015
Title: “Empowering Hospital” – Emp - H.
Call: Project Grants (HP-PJ) 3rd EU Health Programme.
Objective: This multicentre project aims to foster health promotion interventions and environments suitable for prevention of diabetes or cardiovascular diseases. The strategy is based on the Health Promoting Hospitals (HPH) framework with a strong emphasis on evidence based prevention and would operate through a salutogenic approach (WHO Europe 2012) focusing on factors which support human health and well-being.
Health-KIC Innolife (PI: Dr. José Vicente Castell Ripoll, IIS La Fe, Participant)
Title: InnoLife – Better, longer lives.
Call: EIT-2014 Call for Knowledge and Innovation Communities (KICs). KIC Innovation for healthy living and active ageing.
Objective: InnoLife’s mission is to promote entrepreneurship and develop innovations in healthy living and active ageing, providing Europe with new opportunities and resources. This KIC will enable citizens to lead healthier and more productive lives by delivering products, services and concepts that will improve quality of life and contribute to the sustainability of healthcare across Europe. InnoLife is a strong, diverse and balanced partnership of best-in-class organisations in education, research, technology, business creation and corporate and social innovation.
MyCyFAPP (PI: Dr. Carmen Ribes-Konickx, IIS La Fe, Coordinator)
Title: Innovative approach for self-management and social welfare of Cystic Fibrosis patients in Europe: development, validation and implementation of a telematics tool
Call: Horizon 2020, H2020-PHC 26-2014.
Objective: MyCyFAPP aims at the self-management of enzyme replacement in the european cystic fibrosis patients by means of a mobile application (APP) that allows for a personalised and accurate control and monitoring of the disease thanks to interaction between health professionals and patients.
JPI ENPADASI (PI: Dr. Juan Francisco Merino Torres, IIS La Fe, Participant)
Title: The European Nutrition Phenotype Assessment and Data Sharing Initiative.
Call: Joint Programming Initiative a Healthy Diet for a Healthy Life (JPI HDHL) 2014.
Objective: The main objective is to deliver an open access research infrastructure that will contain data from a wide variety of nutritional studies, ranging from mechanistic/interventions to epidemiological studies including a multitude of phenotypic outcomes that will facilitate combined analyses in the future.
Fast metabolomic assessment of donor liver quality prior to transplant. (PI: Dr. Agustín Lahoz, IIS La Fe)
Call: The Roche Organ Transplantation Research Foundation (ROTRF) 2014.
Objective: This project aims to use metabolomic profiles of human livers used for orthotopic transplantation in order to make a quick study of donors before transplantation, evaluating and analysing the adequacy between donor and recipient.
EIP-AHA Reference Site (PI: Dr Bernardo Valdivieso Martínez, IIS La FE)
Title: European Innovation Partnership on Active and Healthy Ageing-Reference sites.
Objective: This guide aims to inform European regions (reference sites) with innovation for active and healthy ageing in real life.
ExPO-r-NeT (PI: Dr. Adela Cañete Nieto, IIS La Fe, Participant)
Title: European Expert Paediatric Oncology Reference Network for Diagnostics and Treatment.
Call: DG SANCO 18.104.22.168. Pilot networks of cooperation under Directive 2011/24/EU (a pilot network of cooperation between paediatric oncology centres).
Objective: ExPO-r-Net is a 3-year project that will build a European Reference Network (ERN) for Paediatric Oncology. The project aims to reduce the current inequalities in childhood cancer survival and healthcare capabilities in different EU Member States.
BeyondSilos (PI: Dr. Bernardo Valdivieso Martínez, IIS La Fe, Participant)
Title: Learning from integrated eCare practice and promoting deployment in European Regions.
Call: Competitiveness and Innovation Framework Programme (CIP). CIP-ICT-PSP.2013.3.1b.
Objective: BeyondSilos is an EU co-funded pilot project that allows providers in seven European regions to implement and pilot integrated social and health care services. A key role in the services will be played by different ICT tools (from home health monitoring to shared data records) that will be utilised to enable better cooperation between care professionals, family members and those receiving care. .
HeCaToS (PI: Dr. José Vicente Castell Ripoll, IIS La Fe, Participant)
Title: Hepatic and Cardiac Toxicity Sustems Modelling.
Call: EU 7th Framework Programme (HEALTH-F4-2013-602156).
Objective: The HeCaToS project aims at developing integrative in silico tools for predicting human liver and heart toxicity. The objective is to develop an integrated modeling framework, by combining advances in computational chemistry and systems toxicology, for modelling toxic perturbations in liver and heart across multiple scales.
Mechaggrenamics (PI: Dr. Rafael Vázquez Manrique, IIS La Fe)
Title: Mechanisms of cell dysfunction by aggregation dynamics of polyQ-containing proteins.
Call: EU FP7-PEOPLE-2012-CIG - Marie-Curie Action: "Career Integration Grants".
Objective: Protein aggregation is a hallmark of several ageing-related neurodegenerative diseases. Different cellular pathways influence the rate of aggregation, and clearance of intermediate protein species and aggregates in the cell. The broad objective of this proposal is to find molecules that modulate protein aggregation. The second objective is to understand the mechanism by which mHtt toxic species alter cellular processes.
RENEB (PI: Dr. Alegría Montoro Pastor, IIS La Fe, Participant)
Title: Realizing the European network of Biodosimetry.
Call: Coordination Action (CSA-CA) within the 7th EU framework EURATOM Fission Programme.
Objective: The goal of RENEB is to establish sustainable European network in biological dosimetry involving laboratories and organisations from 16 countries that can support in a coordinated way the response in case of major nuclear or radiological emergency in Europe.
Innovaliv (PI: Dr. José Vicente Castell Ripoll, IIS La Fe, Participant)
Titlle: Innovative strategies to generate human hepatocytes for treatment of metabolic liver diseases: Tools for personalised cell therapy.
Call: EU FP7-HEALTH-2011.
Objective: InnovaLiv is a collaborative European project aiming at developing innovative tools for personalised cell therapy for the treatment of metabolic liver diseases.
ENCCA (PI: Dr. Adela Cañete Nieto, IIS La Fe, Participant)
Title: European network for Cancer research in children and adolescents.
call: EU FP7-HEALTH-F2-2011.
Objective: The mission of ENCCA is to efficiently structure and enhance collaboration within the field of paediatric oncology in Europe.
EATRIS (PI: Dr. José Vicente Castell Ripoll, IIS La Fe, Participant)
Title: European Infrastructure for Translational Medicine.
Call: EU FP7 CP-CSA. INFRA-2012-1.1.5.
Objective: Translational medicine is the transformation of laboratory research outcomes into new ways to diagnose and treat patients to improve the health of millions of people worldwide. EATRIS provides a new development pathway, open to researchers and companies in need of support for advancing biomedical innovations.