cabecera sugerencias web sanidad web iislafe area del investigador
Regenerative medicine and Heart Transplantation Unit

The Regeneration Research Group is led by Dr. Anastasio Montero (Head of Cardiac Surgery of Hospital La Fe). The group belongs to TERCEL, a national consortium integrated by the main groups focused on cell therapy consortium (RETICS program of Instituto de salud Carlos III). In cooperation with the Prince Felipe Research Centre constitutes the Associated Unit for Cardiovascular Repair IISLAFE-CIPF.

MEMORIA CIENTÍFICA 2014

 

Leading Researcher: Dr. José Anastasio Montero , chef of cardiac surgery montero_jos@gva.es

Contact: Dr. Pilar Sepúlveda pilar.sepulveda.sanchis@gmail.com

 

 

 

Pilar Sepúlveda, Amparo Hernándiz, Akaitz Dorronsorro, Imelda Ontoria, José Luis Diez, Delia Castellano, Marina Piquer, Vicente Miró, Inmaculada Cerrada, Begoña Igual, Vicente Mirabet, Mª Dolores Perez del Caz, Rosa Vives, Mª José Sancho Tello, Pilar Bello, Andrés Castelló, Manuel Pérez, Salvador Torregrosa, Rosario Vicente, Alejandro Vazquez, Ana Bel, Lucía Donate, Tomás Hereida, Francisco José Valera, Elena Sanchez, Francisco Ten Morro, Luis Andrés, Joaquín Osca, Oscar Cano, María Ciria, Hernán González-King, Sandra Tejedor, Helena Grueso, Marta Gómez, Laura Martínez, Alicia Maceira, Juan Cosín-Sales

 

 

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Adult stem cells for the treatment of myocardial infarction. Preclinical studies

Analysis of the ability of mesenchymal and hematopoietic precursor cells to repair the infarcted myocardium. An experimental myocardial infraction rat model develop allows testing the integration capacity of transplanted human cells and monitoring in vivo functional recovery. .

Role of exosomes in cell-cell communication.

Pathological circumstances like ischemia or the lack of nutrients causes changes in the number and composition of exosomes, a type of microvesicles secreted by cells that play a key role in intercellular communication. The role of exosomes in these situation are studied using cell lines, genetically modified animals or experimental models of myocardial infarction and wound healing. .

Valvular pathology

Knowledge of mechanisms involved in valvular degeneration and evaluation of therapeutic implications, through imaging studies of different valve disorders and using primary cultures of valve interstitial cells from patients with valvulopathy. .

Assessment and prevention of reperfusion-induced injury

Analysis of microvascular obstruction and haemorrhage in patients and large animal models of experimental myocardial infarction. Different drugs will be tested as potential candidates to reduce this injury. .

Primary angioplasty in acute myocardial infarction with ST-segment elevation

Assessment of coronary disease pattern of patients referred to the Hemodynamics Laboratory in the acute phase of myocardial infarction, and different factors involved in the prognosis of these patients. .

Diagnosis of cardiac toxicity through a miRNA signature

We are involved in a large european consortium through an FP7 project to model drug induced toxicity in breast cancer patients treated with anthracyclines. miRNA in sera of patients are being analyzed as potential biomarkers of cardiotoxicity. .

Development of electrospinning biodegradable scaffolds for the treatment of skin lesions (ulcers and burn patients)

In collaboration with the Institute of Textil Tecnology (AITEX) and different biotech companies (the most important Solutex S.L and Trompotargets S.L) we are developing new formulations for the treatment of chronic ulcers or to accelerate healing in burn patients.

-Clinical trial in Phase III: open, randomized, multicenter, stratified, active comparator and parallel-group, comparing treatment with 177 Lu-dota0-tyr3-octreotide acetate versus long-acting octreotide in patients with midgut carcinoid tumors, unresectable, progressive and positive for somatostatin receptors. PI: Pilar Bello Arques. Financed by Advanced Accelerator Applications

-Clinical trial in Phase II: BAMI: Efecto de la infusión intracoronaria de céluas madre mononucleadas de médula ósea sobre la mortalidad de cualquier causa en el infarto agudo de miocardio. European comisión.FP7 framework. PI: F. Fernández Aviles.

-Clinical trial in Phase III: RESPOND-CRT: Evaluación de la efectividad de la optimización automática de TRC con el SonR (Sensor hemodinámico) frente a ecocardiográfica para aumentar la tasa de respuesta a TRC. Multicéntrico. Europeo. PI: MJ Sanchotello. Financed by Sorin

-Clinical trial in Phase III: TRICHAMPION Triple Chamber Pacing in Hypertrophic Obstructive Cardiomyopathy (HOCM) Patients. PI: MJ Sanchotello. Financed by Sorin

Hepatic and Cardiac Toxicity Systems modelling (HeCaToS). European Comission. FP7-HEALTH-2013-INNOVATION-1. Reference: CP-IP 602156-1. Oct 2013-Sept 2018 INVESTIGADOR PRINCIPAL: Pilar Sepúlveda/Jose Vicente Castell Ripoll, Financed amount: 1.490.000€.

Red temática de investigación cooperativa en salud convocatoria 2012, Programa RETICS. Red de Terapia Celular TERCEL. RD12/0019/0025. 2017-2021. PI: Pilar Sepúlveda Sanchis, Financed amount: 161.610 €

Terapias innovadoras basadas en la sobreexpresión de HIF-1alfa y Oncostatina M para favorecer la secreción de exosomas terapéuticos en células mesenquimales. Instituto de Salud Carlos III. PI16/107. Jan 2017-Sept 2019, PI: Pilar Sepúlveda Sanchis. Financed amount: 134.915€

Mecanismos moleculares y celulares de las células mesenquimales humanas y de las células cardiacas residentes del adulto en el entorno cardiaco isquémico y el nicho hematopoyético. Instituto de Salud Carlos III (PI13/0414). Jan 2014-Dec 2016. PI: Pilar Sepúlveda Sanchis, Financed amount: 81.000 €

Estudio del daño miocárdico inducido por reperfusión: nuevas estrategias basadas en el uso de microcatéteres. FISABIO con ref. 2014/A/041. Jan 2015-Feb 2017, PI: Jose Luis Diez, Financed Financed amount: 7.000€

PREMICAT. Desarrollo de una estrategia basada en la prevención miocárdica del daño inducido por reperfusión basado en el uso de catéteres y polímeros terapéuticos de nueva generación. ISCIII, proyectos de Desarrollo Tecnológico en Salud (DTS15/0079). Jan 2016-Dec 2017 PI: Pilar Sepúlveda Sanchis, Financed amount: 93.000€

- investigación en el fraccionamiento de aceites enriquecidos con precursores de mediadores lipídicos con actividad anti-inflamatoria y pro-resolutiva. Aplicación al diseño y desarrollo de apósitos para tratamientos de cicatrización de heridas crónicas (RESOLTEX). MINECO RTC-2015-4185-1. Sept 2015 -Dic 2018,PI: Pilar Sepúlveda Sanchis, Financed amount: 1,121,694.70 (HULAFE: 211,463.00 €)

- Investigación de terapias angiogénicas basadas en el factor tisular. RETOS, MINECO RTC-2016-4957-1. (2016-2019). IP: Thrombotargets Europe, S.L. PI: P. Sepúlveda. Financed amount: 706.298€ , (HULAFE: 164.120€).

- Línea de I+D en bioingeniería de aplicaciones dermatológicas basadas en la tecnología de electrospinning, Instituto tecnológico Aitex, Sept 2015-Dic 2018, PI: Pilar Sepúlveda Sanchis, Financed amount: 65.000€

Selected Papers

Cardiomyocyte exosomes regulate glycolytic flux in endothelium by direct transfer of GLUT transporters and glycolytic enzymes Garcia NA, Moncayo-Arlandi J, Sepulveda P, Diez-Juan A Cardiovasc Res 2016 Mar 1;109(3):397-408. D1

Podocalyxin-like protein 1 is a relevant marker for human c-kit (pos) cardiac stem cells. Moscoso I, Tejados N, Barreiro O, Sepúlveda P, Izarra A, Calvo E, Dorronsoro A, Salcedo JM, Sádaba R, Díez-Juan A, Trigueros C, Bernad A. J Tissue Eng Regen Med. 2016 Jul;10(7):580-90. Q1

Pharmacological stress cardiovascular magnetic resonance: feasibility and safety in a large multicentre prospective registry. Monmeneu Menadas JV, Lopez-Lereu MP, Estornell Erill J, Garcia Gonzalez P, Igual Muñoz B, Maceira Gonzalez A. Eur Heart J Cardiovasc Imaging 2016 Mar;17(3):308-15. Q1

Comparison of right ventricular septal pacing and right ventricular apical pacing in patients receiving cardiac resynchronization therapy defibrillators: the SEPTAL CRT Study. Leclercq C, Sadoul N, Mont L, Defaye P, Osca J, Mouton E, Isnard R, Habib G, Zamorano J, Derumeaux G, Fernandez-Lozano I; SEPTAL CRT Study investigators. Eur Heart J 2015 Sep 15. pii: ehv422. Q1

Glucose Starvation in Cardiomyocytes Enhances Exosome Secretion and Promotes Angiogenesis in Endothelial Cells. Garcia, Nahuel A.; Ontoria-Oviedo, Imelda; Gonzalez-King, Hernan; Diez-Juan, Antonio; Sepulveda, Pilar. PLOS ONE. 2015 Sep 22;10(9):e0138849. Q1

Heart valve tissue engineering: how far is the bed side from the bench? Sanz-Garcia A, Oliver-de-la-Cruz J, Mirabet V, Gandía C, Villagrasa A, Sodupe E, Escobedo-Lucea C Expert Rev Mol Med 2015 Sep 24;17:e16. Q1

Involvement of the-420C > G RETN polymorphism in myocardial fibrosis in patients with hypertrophic cardiomyopathy Hernandez-Romero, D.; Orenes-Pinero, E.; Garcia-Honrubia, A.; Climent, V.; Romero-Aniorte, A. I.; Martinez, C. M.; Garcia-Bautista, M.; Martinez, M.; Feliu, E.; Gonzalez, J.; Canovas, S.; Montero-Argudo, J. A.; Valdes, M.; Marin, F. J. Int. Med 2015 Jul;278(1):50-8. Q1

Normal values for cardiovascular magnetic resonance in adults and children Kawel-Boehm N, Maceira A, Valsangiacomo-Buechel ER, Vogel-Claussen J, Turkbey EB, Williams R, Plein S, Tee M, Eng J, Bluemke DA. J Cardiovasc Magn Reson. 2015 Apr 18;17:29. Q1

Targeted Disruption of the SUCNR1 Metabolic Receptor Leads to Dichotomous Effects on Obesity McCreath, Kenneth J.; Espada, Sandra; Galvez, Beatriz G.; Benito, Marina; de Molina, Antonio; Sepulveda, Pilar; Cervera, Ana M. DIABETES. 2015 Apr;64(4):1154-67. D1

TWEAK and NT-proBNP levels predict exercise capacity in hypertrophic cardiomyopathy Hernandez-Romero, Diana; Jover, Eva; Martinez, Carlos M.; Andreu-Cayuelas, Jose M.; Orenes-Pinero, Esteban; Romero-Aniorte, Ana I.; Casas, Teresa; Canovas, Sergio; Montero-Argudo, Jose A.; Valdes, Mariano; de la Morena, Gonzalo; Marin, Francisco. Eur. J. Clin Invest. 2015 Feb;45(2):179-86. Q1

Long term effects of cocaine on the heart assessed by cardiovascular magnetic resonance at 3T. Maceira AM, Ripoll C, Cosin-Sales J, Igual B, Gavilan M, Salazar J, Belloch V, Pennell DJ1. J. Cardiovasc Magn Reson. 2014 Apr 23;16:26. Q1

Human mesenchymal stromal cells modulate T-cell responses through TNF-alpha-mediated activation of NF-kappa B. Dorronsoro, Akaitz; Ferrin, Izaskun; Manuel Salcedo, Juan; Jakobsson, Emma; Fernandez-Rueda, Jon; Lang, Valerie; Sepúlveda, Pilar; Fechter, Karoline; Pennington, Dan; Trigueros, Cesar. Eur. J. Immunol. 2014 Feb;44(2):480-8. Q1

A Comparison of Electrospun Polymers Reveals Poly(3-Hydroxybutyrate) Fiber as a Superior Scaffold for Cardiac Repair. Castellano, Delia; Blanes, Maria; Marco, Bruno; Cerrada, Inmaculada; Ruiz-Sauri, Amparo; Pelacho, Beatriz; Arana, Miriam; Montero, Jose A.; Cambra, Vicente; Prosper, Felipe; Sepúlveda, Pilar. Stem Cells Dev. 2014 Jul 1;23(13):1479-90. Q1

Experience, outcomes and impact of delayed indication for video-assisted wide septal myectomy in 69 consecutive patients with hypertrophic cardiomyopathy. Heredia Cambra, Tomas; Donate Bertolin, Lucia; Bel Minguez, Ana M.; Hernandez Acuna, Carlos E.; Schuler, Mona; Perez Guillen, Manuel; Margarit Calabuig, Juan A.; Montero Argudo, Jose A. Eur. J. Cardiothor Surg. 2013 Aug;44(2):e149-55. Q1

Reference right atrial dimensions and volume estimation by steady state free precession cardiovascular magnetic resonance. Maceira AM1, Cosín-Sales J, Roughton M, Prasad SK, Pennell DJ. J Cardiovasc Magn Reson. 2013 Apr 8;15:29. Q1

A xenogeneic-free protocol for isolation and expansion of human adipose stem cells for clinical uses. Escobedo-Lucea C, Bellver C, Gandia C, Sanz-Garcia A, Esteban FJ, Mirabet V, Forte G, Moreno I, Lezameta M, Ayuso-Sacido A, Garcia-Verdugo JM. Plos One. 2013 Jul 9;8(7):e67870. Q1

Allogenicity of Human Cardiac Stem/Progenitor Cells Orchestrated by Programmed Death Ligand Lauden, Laura; Boukouaci, Wahid; Borlado, Luis R.; Palacios Lopez, Itziar; Sepulveda, Pilar; Tamouza, Ryad; Charron, Dominique; Al-Daccak, Reem Circ Res. 2013 Feb 1;112(3):451-64. D1

Cardiac Cell Therapy: Boosting Mesenchymal Stem Cells Effects Samper E, Diez-Juan A, Montero JA, Sepúlveda P. Stem Cell Rev Rep. 2013 Jun;9(3):266-80. Q1

Hypoxia-inducible factor 1 alpha contributes to cardiac healing in mesenchymal stem cells mediated cardiac repair. I. Cerrada, A. Ruiz-Saurí, R. Carrero, C. Trigueros, A. Dorronsoro, J. M. Sanchez-Puelles, A. Diez-Juan, J.A. Montero, P. Sepúlveda. Stem Cells Dev. 2013 Feb 1;22(3):501-11. Q1

Left ventricular remodeling and hypertrophy in patients with aortic stenosis: insights from cardiovascular magnetic resonance. Dweck MR, Joshi S, Murigu T, Gulati A, Alpendurada F, Jabbour A, Maceira A, Roussin I, Northridge DB, Kilner PJ, Cook SA, Boon NA, Pepper J, Mohiaddin RH, Newby DE, Pennell DJ, Prasad SK. J Cardiovasc Magn Reson. 2012 Jul 28;14:50. 2012 Q1

Time and regeneration in burns treatment: heading into the first worldwide clinical trial with cadaveric mesenchymal stem cells. Mansilla E, Aquino VD, Roque G, Tau JM, Maceira a A. Burns 2012 May;38(3):450-2. Q1

Other papers

A new mutation in the ryanodine receptor 2 gene (RYR2 C2277R) as a cause catecholaminergic polymorphic ventricular tachycardia Domingo D, López-Vilella R, Arnau MÁ, Cano Ó, Fernández-Pons E, Zorio E. Rev Esp Cardiol (Engl Ed) 2015 Jan;68(1):71-3. doi: 10.1016/j.rec.2014.07.022. Epub 2014 Nov 27

Comparative study of functional and structural changes produced in a porcine model of acute and chronic heart attack. Hernándiz A, Cerrada I, Díez JL, Ferrando M, Sepúlveda P.Arch Cardiol Mex.2015 Nov 16. pii: S1405-9940(15)00128-7. doi: 10.1016/j.acmx.2015.09.009.

Cost-effectiveness of rosuvastatin versus simvastatin, atorvastatin and pitavastatin in patients with high and very high cardiovascular risk in Spain Cosin Sales J, Fuentes Jiménez FJ, Mantilla Morató T, Ruiz E, Becerra V, Aceituno S, Ferrario MG, Lizán L, Gracia A Clin Investig Arterioscler 2015 Sep-Oct;27(5):228-38. doi: 10.1016/j.arteri.2014.11.003.

Fontan procedure: imaging of normal post-surgical anatomy and the spectrum of cardiac and extracardiac complications. Navarro-Aguilar, V.; Flors, L.; Calvillo, P.; Merlos, R.; Buendia, F.; Igual, B.; Melero-Ferrer, J.; Rueda Soriano, J.; Leiva-Salinas, C. CLINICAL RADIOLOGY 2015 Mar;70(3):295-303. doi: 10.1016/j.crad.2014.10.005. Epub 2014 Nov 14.

Incidence of Development of Obesity After Heart Transplantation According to the Calcineurin Inhibitor. Lopez-Vilella, R.; Sanchez-Lazaro, I. J.; Martinez-Dolz, L.; Almenar-Bonet, L.; Marques-Sule, E.; Melero-Ferrer, J.; Portoles-Sanz, M.; Rivera-Otero, M.; Domingo-Valero, D.; Montero-Argudo, A. TRANSPLANTATION PROCEEDINGS. 2015 Jan-Feb;47(1):127-9. doi:10.1016/j.transproceed.2014.11.025.

Initial Experience with a New Image Integration Module Designed for Reducing Radiation Exposure During Electrophysiological Ablation Procedures Cano Ó, Alonso P, Osca J, Andrés A, Sancho-Tello MJ, Olagüe J, Salvador A, Martínez-Dolz L.J Cardiovasc Electrophysiol 2015 Jun;26(6):662-70. doi: 10.1111/jce.12659. Epub 2015 Apr 29.

Phase information of time-frequency transforms as a key feature for classification of atrial fibrillation episodes. Ortigosa, Nuria; Fernandez, Carmen; Galbis, Antonio; Cano, Oscar PHYSIOLOGICAL MEASUREMENT. 2015 Mar;36(3):409-24. doi: 10.1088/0967-3334/36/3/409. Epub 2015 Feb 5.

Quality Markers in Cardiology. Main Markers to Measure Quality of Results (Outcomes) and Quality Measures Related to Better Results in Clinical Practice (Performance Metrics). INCARDIO (Indicadores de Calidad en Unidades Asistenciales del Área del Corazón): A SEC/SECTCV Consensus Position Paper López-Sendón J, González-Juanatey JR, Pinto F, Cuenca Castillo J, Badimón L, Dalmau R, González Torrecilla E, López-Mínguez JR, Maceira AM, Pascual-Figal D, Pomar Moya-Prats JL, Sionis A, Zamorano JL; INCARDIO Task Force (Indicadores de Calidad en Unidades Asistenciales del Área del Corazón) joint Sociedad Española de Cardiología and Sociedad Española de Cirugía Torácica Cardiovascular task forcé. Rev Esp Cardiol (Engl Ed. 2015 Nov;68(11):976-995.e10. doi: 10.1016/j.rec.2015.07.003. Epub 2015 Aug 25.

QUANTITATIVE APPROACH TO ASSIST NEUROBLASTOMA ASSESSMENT BY MEASURING I-123 mIBG UPTAKE IN SCINTIGRAPHIC IMAGES Martinez-Diaz, Rafael; Balaguer, Julia; Sanchez Ruiz, Luis Manuel; Bello, Pilar; Castel, Victoria; Rivas, Antonio; Canete, Adela; Falgas, Marina; Luis Loaiza, Jose; Peris-Fajarnes, Guillermo IMAGE ANALYSIS & STEREOLOGY 2015; Volumen: 34 Número: 2 Páginas: 135-144

Response to ECG, October 2015.Cano, Oscar. Revista espanola de cardiologia (English ed.) 2015 Nov;68(11):1026. doi: 10.1016/j.rec.2015.05.005.

Systematic Implantation of Pacemaker/ICDs under Active Oral Anticoagulation Irrespective of Patient's Individual Preoperative Thromboembolic Risk Cano Ó, Andrés A, Jiménez R, Osca J, Alonso P, Rodríguez Y, Sancho-Tello MJ, Olagüe J, Castro JE, Salvador A, Martínez-Dolz L Pacing Clin Electrophysiol 2015 Jun;38(6):723-30. doi: 10.1111/pace.12613. Epub 2015 Mar 25.

The genetic background of left ventricular hypertrabeculation/noncompaction remains vague. Response. Rodríguez-Serrano M, Domingo D, Igual B, Zorio E Rev Esp Cardiol (Engl Ed) 2015 Feb;68(2):167-8. doi: 10.1016/j.rec.2014.10.001. Epub 2014 Dec 15.

The use of multisite left ventricular pacing via quadripolar lead improves acute haemodynamics and mechanical dyssynchrony assessed by radial strain speckle tracking: initial results Osca J, Alonso P, Cano O, Andrés A, Miro V, Tello MJ, Olagüe J, Martínez L, Salvador A Europace. 2015 Sep 1. pii: euv211.

The use of quadripolar left ventricular leads improves the hemodynamic response to cardiac resynchronization therapy Osca J, Alonso P, Cano Ó, Sánchez JM, Tejada D, Andrés A, Sancho Tello MJ, Olagüe J Pacing Clin Electrophysiol. 2015 Mar;38(3):326-33. doi: 10.1111/pace.12545.

Time evolution of in vivo articular cartilage repair induced by bone marrow stimulation and scaffold implantation in rabbits Sancho-Tello M, Forriol F, Gastaldi P, Ruiz-Saurí A, Martín de Llano JJ, Novella-Maestre E, Antolinos-Turpín CM, Gómez-Tejedor JA, Gómez Ribelles JL, Carda C. Int J Artif Organs 2015 Apr;38(4):210-23. doi: 10.5301/ijao.5000404. Epub 2015 Apr 29.

Value of the Electrocardiogram as a Predictor of Right Ventricular Dysfunction in Patients With Chronic Right Ventricular Volume Overload Alonso, Pau; Andres, Ana; Rueda, Joaquin; Buendia, Francisco; Igual, Begona; Rodriguez, Maria; Osa, Ana; Arnau, Miguel A.; Salvador, Antonio REVISTA ESPANOLA DE CARDIOLOGIA 2015 May;68(5):390-7. doi: 10.1016/j.rec.2014.04.019. Epub 2014 Oct 7.

Atrial fibrillation subtypes classification using the General Fourier-family Transform Ortigosa N, Cano O, Ayala G, Galbis A, Fernández C. Med Eng Phys 2014 Apr;36(4):554-60. doi: 10.1016/j.medengphy.2013.12.005. Epub 2013 Dec 28.

Comments on the 2013 ESC Guidelines on Cardiac Pacing and Cardiac Resynchronization Therapy. Spanish Society of Cardiology Working Group for the 2013 ESC Guidelines on Cardiac Pacing and Cardial Resynchronization Therapy, Fernández Lozano I, Mateas FR, Osca J, Sancho Tello MJ, García Bolao I, Martínez Ferrer J, Fidalgo Andrés ML, Rodríguez García J; Expert

Reviewers for the 2013 ESC Guidelines on Cardiac Pacing and Resynchronization Therapy, Leal del Ojo J, Ripoll Vera T, Coma Sanmartín R, Cano Pérez O, Pombo Jimenez M, Medina Palomo C, Pérez Álvarez L, Hernández Madrid A, Perez Castellano N, Mont Girbau L, Mitjans AM, Arribas F, Merino Llorens JL, Pérez Villacastín J, Alzueta Rodriguez J, Carmona Salinas JR; Clinical Practice Guidelines Committee of the Spanish Society of Cardiology, Fernández-Ortiz A, Alonso AM, Anguita M, Cequier Á, Comín J, Diaz-Buschmann I, Fernández Lozano I, Gómez de Diego JJ, Pan M, Worner F. Rev Esp Cardiol (Engl Ed). 2014 Jan;67(1):6-14. doi: 10.1016/j.rec.2013.11.002.

 

Spanish Pacemaker Registry. Eleventh official report of the Spanish Society of Cardiology Working Group on Cardiac Pacing (2013). Coma Samartín R, Cano Pérez Ó, Pombo Jiménez M.Rev Esp Cardiol (Engl Ed) 2014 Dec;67(12):1024-38. doi:10.1016/j.rec.2014.08.004. Epub 2014 Nov 11.

Triple cardiac rupture Vazquez, Alejandro; Osa, Ana; Vicente, Rosario; Montero, Jose A. INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY 2014 Sep;19(3):535-6. doi: 10.1093/icvts/ivu170. Epub 2014 May 29.

miR-133a enhances the protective capacity of cardiac progenitors cells after myocardial infarction. Izarra A, Moscoso I, Levent E, Cañón S, Cerrada I, Díez-Juan A, Blanca V, Núñez-Gil IJ, Valiente I, Ruíz-Sauri A, Sepúlveda P, Tiburcy M, Zimmermann WH, Bernad A. Stem Cell Reports 2014 Dec 9;3(6):1029-42. doi: 10.1016/j.stemcr.2014.10.010.

Metabolic syndrome in heart transplantation: impact on survival and renal function. Martinez-Dolz, Luis; Sanchez-Lazaro, Ignacio J.; Almenar-Bonet, Luis; Portoles, Manuel; Rivera, Miguel; Salvador, Antonio; Anastasio Montero, Jose Transplant International. 2013 Sep;26(9):910-8.

Cost-effectiveness of rosuvastatin versus simvastatin, atorvastatin and pitavastatin in patients with high and very high cardiovascular risk in Spain]. Cosin Sales J, Fuentes Jiménez FJ, Mantilla Morató T, Ruiz E, Becerra V, Aceituno S, Ferrario MG, Lizán L, Gracia A. Clin Investig Arterioscler. 2015 Sep-Oct;27(5):228-38. doi: 10.1016/j.arteri.2014 2015

Does sex affect anticoagulant use for stroke prevention in nonvalvular atrial fibrillation? The prospective global anticoagulant registry in the FIELD-Atrial Fibrillation. Lip GY, Rushton-Smith SK, Goldhaber SZ, Fitzmaurice DA, Mantovani LG, Goto S, Haas S, Bassand JP, Camm AJ, Ambrosio G, Janský P, Al Mahmeed W, Oh S, van Eickels M, Raatikainen P, Steffel J, Oto A, Kayani G, Accetta G, Kakkar AK; GARFIELD-AF Investigators.Circ Cardiovasc Qual Outcomes. 2015 Mar;8(2 Suppl 1):S12-20. doi: 10.1161/CIRCOUTCOMES.114.001556. Epub 2015 Feb 24.

Quality Markers in Cardiology. Main Markers to Measure Quality of Results (Outcomes) and Quality Measures Related to Better Results in Clinical Practice (Performance Metrics). INCARDIO (Indicadores de Calidad en Unidades Asistenciales del Área del Corazón): A SEC/SECTCV Consensus Position Paper. López-Sendón J, González-Juanatey JR, Pinto F, Cuenca Castillo J, Badimón L, Dalmau R, González Torrecilla E, López-Mínguez JR, Maceira AM, Pascual-Figal D, Pomar Moya-Prats JL, Sionis A, Zamorano J Rev Esp Cardiol (Engl Ed 2015 Nov;68(11):976-995.e10. doi: 10.1016/j.rec.2015.07.003.

[Nocardia farcinica lung infection in a patient with cystic fibrosis and a lung transplant]. Chacón CF, Vicente R, Ramos F, Porta J, Lopez Maldonado A, Ansotegui E.Rev Esp Anestesiol Reanim.2015 Mar;62(3):161-4. doi: 10.1016/j.redar.2014.04.010

 

Cardiovascular magnetic resonance determinants of left ventricular noncompaction. Dawson DK, McLernon DJ, Raj VJ, Maceira AM, Prasad S, Frenneaux MP, Pennell DJ, Kilner PJ. Am J Cardiol. 2014 Aug 1;114(3):456-62. doi: 10.1016/j.amjcard.2014.05.017

Hepatitis B transmission by cell and tissue allografts: how safe is safe enough? Solves P, Mirabet V, Alvarez M. World J Gastroenterol 2014 Jun 21;20(23):7434-41.

Improving ovarian tissue cryopreservation for oncologic patients: slow freezing versus vitrification, effect of different procedures and devices.Herraiz S, Novella-Maestre E, Rodríguez B, Díaz C, Sánchez-Serrano M, Mirabet V, Pellicer A.Fertil Steril. 2014 Mar;101(3):775-84

 

Diagnostic power of echocardiographic speckle tracking of the tricuspid annular motion to assess right ventricular dysfunction. Alonso P, Andrés A, Miró V, Igual B, Sánchez I, Salvador AInt J Cardiol. 2014;172(1):e218-9. doi: 10.1016/j.ijcard.2013.12.157.

Extracorporeal membrane oxygenation in primary graft dysfunction in a paediatric double lung transplant: presentation of a case. López-Cantero M, Grisolía AL, Vicente R, Moreno I, Ramos F, Porta J, Torregrosa S. Rev Esp Anestesiol Reanim. 2014 Apr;61(4):205-8.

Model generation of coronary artery bifurcations from CTA and single plane angiography Cárdenes R, Díez JL, Larrabide I, Bogunovi? H, Frangi AF. Med Phys 2013 Jan;40(1):013701.

Patients with cardiac disease: Changes observed through last decade in out-patient clinics. Cordero A1, Bertomeu-Martínez V, Mazón P, Fácila L, Cosín J, Bertomeu-González V, Rodriguez M, Andrés E, Galve E, Lekuona I, González-Juanatey JR.World J Cardiol. 2013 Aug 26;5(8):288-94

Predictores de mortalidad hospitalaria y a medio plazo tras el reemplazo valvular aórtico transcatéter: datos del registro nacional TAVI 2010-2011 Elena Sánchez Lacuesta, Francisco Ten Morro, Anastasio Montero Rev Esp Cardiol 2013; 66(12): 949-958

Qualitative and quantitative cell recovery in umbilical cord blood processed by two automated devices in routine cord blood banking: a comparative study. Solves P, Planelles D, Mirabet V, Blanquer A, Carbonell-Uberos F Blood Transfus 2013 Jul;11(3):405-11.

Sum of effects of myocardial ischemia followed by ellectrically induced tachycardia on myocardial function. Díez JL, Hernándiz A, Cosín J, Aguilar A, Portolés M. Med Sci Monit Basic Res. 2013 May 31;19:153-62

Utility of Multidector Computed Tomography for Postprocedure Evaluation of Endovascular Aortic Stent-grafts. Estornell-Erill J, García-García R, Igual-Muñoz B, Gil-Alberola O, Talens-Ferrando A, Ridocci-Soriano F Rev Esp Cardiol 2013 Apr;66(4):316-7.

Model generation of coronary artery bifurcations from CTA and single plane angiographyCárdenes R, Díez JL, Duchateau N, Pashaei A, Frangi AF Med Phys 2013 Jan;40(1):013701.

Patient-specific simulations of stenting procedures in coronary bifurcations:two clinical casesMorlacchi S, Colleoni SG, Cárdenes R, Chiastra C, Díez JL, Larrabide I, Migliavacca F Medical Engineering & Physics. 2013; 35:1272-81. 2013 Sep;35(9):1272-81.

Conditioned media from adipose-tissue-derived mesenchymal stem cells downregulate degradative mediators induced by interleukin-1? in osteoarthritic chondrocytes. Platas J, Guillén MI, del Caz MD, Gomar F, Mirabet V, Alcaraz MJ. Mediators Inflamm. 2013;2013:357014.

Qualitative and quantitative cell recovery in umbilical cord blood processed by two automated devices in routine cord blood banking: a comparative study. Solves P, Planelles D, Mirabet V, Blanquer A, Carbonell-Uberos F Blood Transfus 2013 Jul;11(3):405-11.

Extracorporeal membrane oxygenation in lung transplantation. Vicente R, Moreno I, Soria A, Ramos F, Torregrosa S. Med Intensiva. 2013 Mar;37(2):110-5.

Antifungal prophylaxis in the postoperative period of lung transplant surgery in Spain. Sacanell J, Rey T, López E, Vicente R, Ballesteros MA, Iranzo R, Robles JC, Restrepo MI, Rello J.Med Intensiva. 2013 Apr;37(3):201-5. doi: 10.1016/j.medin.2012.10.003

Cord blood quality after vaginal and cesarean deliveries. Solves P, Perales A, Fillol M, Bonilla-Musoles F, Mirabet V. Transfusion. 2012 Sep;52(9):2064-6. doi: 10.1111/j.1537-2995.2012.03704.

Diagnóstico etiológico de la disfunción ventricular izquierda con tomografía computarizada: comparación con coronariografía y cardiorresonancia. Estornell-Erill J, Igual-Muñoz B, Monmeneu-Menadas JV, Soriano-Navarro C, Valle-Muñoz A, Vilar-Herrero JV, Perez-Bosca L, Paya-Serrano R, Martinez-Alzamora N, Ridocci-Soriano F Rev Esp Cardiol 2012 Jun;65(6):517-24.

Evaluation of a new standardized protocol for the perioperative management of chronically anticoagulated patients receiving implantable cardiac arrhythmia devices. Cano O, Muñoz B, Tejada D, Osca J, Sancho-Tello MJ, Olagüe J, Castro JE, Salvador A Heart Rhythm 2012 Mar;9(3):361-7.

Heme oxygenase-1 mediates protective effects on inflammatory, catabolic and senescence responses induced by interleukin-1? in osteoarthritic osteoblasts. Clérigues V, Guillén MI, Castejón MA, Gomar F, Mirabet V, Alcaraz MJ Biochem Pharmacol 2012 Feb 1;83(3):395-405.

IL-1B induces mesenchymal stem cells migration and leucocyte chemotaxis through NF-kB signaling pathway. R. Carrero, I. Cerrada, E. Lledó, J. Dopazo, F. García, M.P. Rubio, C. Trigueros, A. Dorronsoro, A. Ruiz-Saurí, J.A. Montero, P. Sepúlveda.Stem Cells Reviews and reports. 2012 Sep;8(3):905-16.

Presence of hydroxy ethyl starch increases the false positive anti-HIV test results in cord blood samples. Solves P, Alvarez M, Mirabet V Int Jnl Lab Hem 2012 Dec;34(6):e7-e8.

Recidiva de hipertiroidismo en una paciente con enfermedad de Graves tiroidectomizada hace 15 años. L.Vercher-Conejero, A. Rivas Sanchez, P. Bello Arques, C. Ruiz Llorca , M. Falgás Lacueva, L. Pelegri Martinez. Rev Esp Med Nucl 2012 Mar-Apr;31(2):108-9.

Use of liquid nitrogen during storage in a cell and tissue bank: Contamination risk and effect on the detectability of potential viral contaminants. Mirabet V, Alvarez M, Solves P, Ocete D, Gimeno C.Cryobiology 2012 Apr;64(2):121-3. doi: 10.1016/j.cryobiol.2011.12.005. Epub 2011 Dec 28.