Joint Research Unit in in Molecular mechanisms of Drug adverse reactions
The Joint Research Unit on Molecular Mechanisms (Chemical and Biological) of Adverse Drug Reactions with Prof. Miguel A. Miranda as leader, was created upon agreement between IIS-La Fe and Technical University of Valencia (UPV), as a result of a long-lasting and productive collaboration between these entities. The unit is integrated by several researchers: emerging researchers, established researchers, associated researchers, postdoctoral and predoctoral. In this unit, research at the chemistry-biology interface is addressed. In this unit, research at the chemistry-biology interface is addressed. Specifically, the unit has extensive experience on the elucidation of photochemical mechanisms, especially on the photosensitized reactions of biomolecules (proteins, DNA and lipids). The main contributions to this field lie in the discovery of the photophysical and photochemical aspects of photosensitization by drugs, covalent and non-covalent binding of drugs to proteins by ultraviolet radiation, as well as the formation and repair of bipyrimidinic DNA damage.