Hepatología experimental y trasplante hepático

Publicaciones

Septic Participation in Cardiogenic Shock: Exposure to Bacterial Endotoxin.

Ramirez P, Villarreal E, Gordon M, Gómez MD, de Hevia L, Vacacela K, Gisbert T, Quinzá A, Ruiz J, Alonso R, Bonastre J, Vila J Shock (47) 588-592.
[doi:10.1097/SHK.0000000000000798]

Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies.

Donato MT, Gómez-Lechón MJ, Tolosa L EXPERT OPIN DRUG DIS (12) 201-211.
[doi:10.1080/17460441.2017.1271784]

Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing.

Gómez-Lechón MJ, Tolosa L, Donato MT EXPERT OPIN DRUG MET (13) 137-148.
[doi:10.1080/17425255.2017.1238459]

Hepatitis C-related cirrhosis. Current status.

Conde I, Vinaixa C, Berenguer M MED CLIN-BARCELONA (148) 78-85.
[doi:10.1016/j.medcli.2016.09.019]

Efficacy of hydrodynamic interleukin 10 gene transfer in human liver segments with interest in transplantation.

Sendra Gisbert L, Miguel Matas A, Sabater Ortí L, Herrero MJ, Sabater Olivas L, Montalvá Orón EM, Frasson M, Abargues López R, López-Andújar R, García-Granero Ximénez E, Aliño Pellicer SF LIVER TRANSPLANT (23) 50-62.
[doi:10.1002/lt.24667]

Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies

Donato, MT., Gómez Lechón, MJ., Tolosa, L Toxicology and applied pharmacology (12) 201-211.

Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing

Gómez Lechón, MJ., Tolosa, L, Donato, MT. Toxicology and applied pharmacology (13) 137-148.

New microRNA Biomarkers for Drug-Induced Steatosis and Their Potential to Predict the Contribution of Drugs to Non-alcoholic Fatty Liver Disease

López, M., Conde, Isabel, Tolosa, L, Zaragozá, Ángela, Castell, José V, Gómez Lechón, MJ., Jover, Ramiro Toxicology and applied pharmacology -.

Dysfunctional mitochondrial fission impairs cell reprogramming.

Prieto J, León M, Ponsoda X, García-García F, Bort R, Serna E, Barneo-Muñoz M, Palau F, Dopazo J, López-García C, Torres J Cell cycle (Georgetown, Tex.) (15) 3240-3250.
[doi:10.1080/15384101.2016.1241930]

Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development.

Donato MT, López-Riera M, Castell JV, Gómez-Lechón MJ, Jover R TOXICOL LETT (263) 58-67.
[doi:10.1016/j.toxlet.2016.10.008]

Twenty-five years of ambulatory laparoscopic cholecystectomy.

Bueno Lledó J, Granero Castro P, Gomez I Gavara I, Ibañez Cirión JL, López Andújar R, García Granero E CIR ESPAN (94) 429-441.
[doi:10.1016/j.ciresp.2015.03.012]

Iberogast-Induced Severe Hepatotoxicity Leading to Liver Transplantation.

Sáez-González E, Conde I, Díaz-Jaime FC, Benlloch S, Prieto M, Berenguer M AM J GASTROENTEROL (111) 1364-1365.
[doi:10.1038/ajg.2016.260]

Conservative treatment of hepatic inflammatory pseudotumor.

Ballester-Pla N, García-Domínguez R, Pérez-Girbes A, Orbis-Castellanos JF, Pareja E CIR ESPAN (94) 422-424.
[doi:10.1016/j.ciresp.2015.05.008]

Silencing of hepatic fate-conversion factors induce tumorigenesis in reprogrammed hepatic progenitor-like cells.

Serrano F, García-Bravo M, Blazquez M, Torres J, Castell JV, Segovia JC, Bort R STEM CELL RES THER (7) 96-96.
[doi:10.1186/s13287-016-0349-5]

Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing.

Tolosa L, Gómez-Lechón MJ, López S, Guzmán C, Castell JV, Donato MT, Jover R Toxicological sciences : an official journal of the Society of Toxicology (152) 214-229.
[doi:10.1093/toxsci/kfw078]

A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury.

García-Cañaveras JC, Castell JV, Donato MT, Lahoz A SCIENTIFIC REPORTS (6) 27239-27239.
[doi:10.1038/srep27239]

Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis.

Tolosa L, Gómez-Lechón MJ, Jiménez N, Hervás D, Jover R, Donato MT Toxicology and Applied Pharmacology -.

Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming.

Prieto J, León M, Ponsoda X, Sendra R, Bort R, Ferrer-Lorente R, Raya A, López-García C, Torres J NAT COMMUN (7) 11124-11124.
[doi:10.1038/ncomms11124]

Surgical anterior cavoplasty for managing a case of early acute outflow obstruction after liver transplantation.

Ibáñez V, Montalvá E, Vila JJ, López-Andújar R PEDIATR TRANSPLANT (20) 151-154.
[doi:10.1111/petr.12629]

Malignizacio´n de quiste de cole´doco en edad adulta: una entidad poco frecuente.

Aguilar Martí MD, Montalvá Oron EM, Ballester Pla N, Pérez Rojas J, López Andújar R CIR ESPAN (94) e41-3-.
[doi:10.1016/j.ciresp.2014.11.008]

Extending metabolome coverage for untargeted metabolite profiling of adherent cultured hepatic cells.

García-Cañaveras JC, López S, Castell JV, Donato MT, Lahoz A ANAL BIOANAL CHEM (408) 1217-1230.
[doi:10.1007/s00216-015-9227-8]

Hepatocyte transplantation program: Lessons learned and future strategies.

Ibars EP, Cortes M, Tolosa L, Gómez-Lechón MJ, López S, Castell JV, Mir J WORLD J GASTROENTERO (22) 874-886.
[doi:10.3748/wjg.v22.i2.874]

Is physical exercise harmful to liver transplantation recipients? Review of literature.

Moya-Nájera D, Borreani S, Moya-Herraiz Á, Calatayud J, López-Andújar R, Colado JC CIR ESPAN (94) 4-10.
[doi:10.1016/j.ciresp.2015.07.002]

cGMP-Phosphodiesterase Inhibition Prevents Hypoxia-Induced Cell Death Activation in Porcine Retinal Explants.

Olivares-González L, Martínez-Fernández de la Cámara C, Hervás D, Marín MP, Lahoz A, Millán JM, Rodrigo R Plos One (11) e0166717-.
[doi:10.1371/journal.pone.0166717]

cGMP-Phosphodiesterase Inhibition Prevents Hypoxia-Induced Cell Death Activation in Porcine Retinal Explants.

Olivares-González L, Martínez-Fernández de la Cámara C, Hervás D, Marín MP, Lahoz A, Millán JM, Rodrigo R Plos One -.

Studying Closed Hydrodynamic Models of "In Vivo" DNA Perfusion in Pig Liver for Gene Therapy Translation to Humans.

Sendra L, Miguel A, Pérez-Enguix D, Herrero MJ, Montalvá E, García-Gimeno MA, Noguera I, Díaz A, Pérez J, Sanz P, López-Andújar R, Martí-Bonmatí L, Aliño SF Plos One (11) e0163898-.
[doi:10.1371/journal.pone.0163898]

Hepatocyte transplantation program: Lessons learned and future strategies.

Ibars, EP., Cortes, M., Tolosa, L, Gómez Lechón, MJ., López, S., Castell, JV., Mir, J. World journal of gastroenterology (22) 874-960.

Transplantation of hESC-derived hepatocytes protects mice from liver injury.

Tolosa L, Caron J, Hannoun Z, Antoni M, López S, Burks D, Castell JV, Weber A, Gomez-Lechon MJ, Dubart-Kupperschmitt A STEM CELL RES THER (6) 246-246.
[doi:10.1186/s13287-015-0227-6]

Alterations in carbohydrate metabolism in cirrhotic patients before and after liver transplant.

Ramos-Prol A, Hervás-Marín D, Rodríguez-Medina B, Campos-Alborg V, Berenguer M, Moya-Herraiz Á, Merino-Torres JF DIABETES RESEARCH AND CLINICAL PRACTICE (110) 123-128.
[doi:10.1016/j.diabres.2015.10.002]

Metagenomic Analysis of Crohn's Disease Patients Identifies Changes in the Virome and Microbiome Related to Disease Status and Therapy, and Detects Potential Interactions and Biomarkers

Pérez-Brocal V, García-López R, Nos P, Beltrán B, Moret I, Moya A INFLAMMATORY BOWEL DISEASES (21) 2515-2532.
[doi:10.1097/MIB.0000000000000549]

The value of serum aspartate aminotransferase and gamma-glutamyl transpetidase as biomarkers in hepatotoxicity.

Robles-Diaz M, Garcia-Cortes M, Medina-Caliz I, Gonzalez-Jimenez A, Gonzalez-Grande R, Navarro JM, Castiella A, Zapata EM, Romero-Gomez M, Blanco S, Soriano G, Hidalgo R, Ortega-Torres M, Clavijo E, Bermudez-Ruiz PM, Lucena MI, Andrade RJ, Spanish DILI Registry, Faster Evidence-based Translation (SAFE-T) Consortium LIVER INT (35) 2474-2482.
[doi:10.1111/liv.12834]

High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins.

Tolosa L, Carmona A, Castell JV, Gómez-Lechón MJ, Donato MT ARCH TOXICOL (89) 1847-1860.
[doi:10.1007/s00204-014-1334-3]

TH and DCX mRNAs in peripheral blood and bone marrow predict outcome in metastatic neuroblastoma patients.

Yáñez Y, Hervás D, Grau E, Oltra S, Pérez G, Palanca S, Bermúdez M, Márquez C, Cañete A, Castel V Journal of cancer research and clinical oncology -.

Alterations in carbohydrate metabolism in cirrhotic patients before and after liver transplant.

Ramos-Prol A, Hervás-Marín D, Rodríguez-Medina B, Campos-Alborg V, Berenguer M, Moya-Herraiz Á, Merino-Torres JF DIABETES RESEARCH AND CLINICAL PRACTICE -.

[It's not pneumonia, it's a diaphragmatic hernia].

Carazo Palacios ME, Ibáñez Pradas V, Llorens Salvador R, Lluna González J, Rodríguez Iglesias P AN PEDIATR (83) 140-141.
[doi:10.1016/j.anpedi.2015.02.011]

Monosegment ALPPS: A new variant of the techniques for rapid hepatic regeneration. Critical review of the initial results of our series.

Montalvá Orón EM, Maupoey Ibáñez J, Bañuelos Carrillo R, Boscà Robledo A, Orbis Castellanos JF, Moya Herraiz Á, Ballester Vallés C, Pérez Rojas J, Aparicio Urtasun J, López-Andújar R CIR ESPAN (93) 436-443.
[doi:10.1016/j.ciresp.2015.02.011]

Renal function improvement in liver transplant recipients after early everolimus conversion: A clinical practice cohort study in Spain.

Bilbao I, Salcedo M, Gómez MA, Jimenez C, Castroagudín J, Fabregat J, Almohalla C, Herrero I, Cuervas-Mons V, Otero A, Rubín A, Miras M, Rodrigo J, Serrano T, Crespo G, De la Mata M, Bustamante J, Gonzalez-Dieguez ML, Moreno A, Narvaez I, Guilera M, EVEROLIVER study group LIVER TRANSPLANT (21) 1056-1065.
[doi:10.1002/lt.24172]

The histone deacetylase sirtuin 2 is a new player in the regulation of platelet function.

Moscardó A, Vallés J, Latorre A, Jover R, Santos MT Journal of thrombosis and haemostasis : JTH (13) 1335-1344.
[doi:10.1111/jth.13004]

Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design.

Castaño-Vinyals G, Aragonés N, Pérez-Gómez B, Martín V, Llorca J, Moreno V, Altzibar JM, Ardanaz E, de Sanjosé S, Jiménez-Moleón JJ, Tardón A, Alguacil J, Peiró R, Marcos-Gragera R, Navarro C, Pollán M, Kogevinas M, MCC-Spain Study Group GAC SANIT (29) 308-315.
[doi:10.1016/j.gaceta.2014.12.003]

High-content screening technology for studying drug-induced hepatotoxicity in cell models.

Tolosa L, Gómez-Lechón MJ, Donato MT ARCH TOXICOL (89) 1007-1022.
[doi:10.1007/s00204-015-1503-z]

Growth-promoting and tumourigenic activity of c-Myc is suppressed by Hhex.

Marfil V, Blazquez M, Serrano F, Castell JV, Bort R Oncogene (34) 3011-3022.
[doi:10.1038/onc.2014.240]

Human neonatal hepatocyte transplantation induces long-term rescue of unconjugated hyperbilirubinemia in the Gunn rat.

Tolosa L, López S, Pareja E, Donato MT, Myara A, Nguyen TH, Castell JV, Gómez-Lechón MJ LIVER TRANSPLANT (21) 801-811.
[doi:10.1002/lt.24121]

Reply to Letter: "A Question Seeking for an Answer: Use of T-tube in the Era of Liver Transplantation With Grafts From Extended Criteria Donors and Donors After Cardiac Death".

López-Andújar R, Montalvá EM, Vergara FA ANN SURG (261) e174-5-.
[doi:10.1097/SLA.0000000000000722]

Tumor seudopapilar sólido del páncreas: presentación de un caso y revisión del tema.

Leonher-Ruezga K, Lopez-Espinosa S, Moya Herraiz A, Perez Rojas J, López Andújar R CIR ESPAN (93) e37-40-.
[doi:10.1016/j.ciresp.2013.04.007]

Framingham score, renal dysfunction, and cardiovascular risk in liver transplant patients

Di Maira, Tommaso, Rubin, Angel, Puchades, Lorena, Aguilera, Victoria, Vinaixa, Carmen, Garcia, Maria, De Maria, Nicola, Villa, Erica, Lopez-Andujar, Rafael, San Juan, Fernando, Montalva, Eva, Perez, Judith, Prieto, Martin, Berenguer, Marina LIVER TRANSPLANT (21) 812-822.

Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver disease.

Pisonero-Vaquero S, Martínez-Ferreras Á, García-Mediavilla MV, Martínez-Flórez S, Fernández A, Benet M, Olcoz JL, Jover R, González-Gallego J, Sánchez-Campos S MOL NUTR FOOD RES (59) 879-893.
[doi:10.1002/mnfr.201400913]

Cooperative Study of the Spanish Pancreas Transplant Group (GETP): Surgical Complications.

Moya-Herraiz A, Muñoz-Bellvis L, Ferrer-Fábrega J, Manrique Municio A, Pérez-Daga JA, Muñoz-Casares C, Alarcó-Hernández A, Gómez-Gutiérrez M, Casanova-Rituerto D, Sanchez-Bueno F, Jimenez-Romero C, Fernández-Cruz Pérez L CIR ESPAN (93) 300-306.
[doi:10.1016/j.ciresp.2014.12.006]

Sofosbuvir compassionate use program for patients with severe recurrent hepatitis C after liver transplantation.

Forns X, Charlton M, Denning J, McHutchison JG, Symonds WT, Brainard D, Brandt-Sarif T, Chang P, Kivett V, Castells L, Prieto M, Fontana RJ, Baumert TF, Coilly A, Londoño MC, Habersetzer F Hepatology (61) 1485-1494.
[doi:10.1002/hep.27681]

Hepatitis B virus quasispecies evolution after liver transplantation in patients under long-term lamivudine prophylaxis with or without hepatitis B immune globulin.

Buti M, Tabernero D, Mas A, Homs M, Prieto M, Rodríguez-Frías F, Casafont F, Casillas R, González A, Miras M, Herrero JI, Castells L, Esteban R TRANSPL INFECT DIS (17) 208-220.
[doi:10.1111/tid.12360]

Repression of the nuclear receptor small heterodimer partner by steatotic drugs and in advanced nonalcoholic fatty liver disease.

Benet M, Guzmán C, Pisonero-Vaquero S, García-Mediavilla MV, Sánchez-Campos S, Martínez-Chantar ML, Donato MT, Castell JV, Jover R MOL PHARMACOL (87) 582-594.
[doi:10.1124/mol.114.096313]

Comparison of the prognostic value of liver biopsy and FIB-4 index in patients coinfected with HIV and hepatitis C virus.

Berenguer J, Zamora FX, Aldámiz-Echevarría T, Von Wichmann MA, Crespo M, López-Aldeguer J, Carrero A, Montes M, Quereda C, Téllez MJ, Galindo MJ, Sanz J, Santos I, Guardiola JM, Barros C, Ortega E, Pulido F, Rubio R, Mallolas J, Tural C, Jusdado JJ, Pérez G, Díez C, Álvarez-Pellicer J, Esteban H, Bellón JM, González-García J, Grupo de Estudio del SIDA (GESIDA) HIV/HCV Cohort Study Group CLIN INFECT DIS (60) 950-958.
[doi:10.1093/cid/ciu939]

Presentación de 2 casos clínicos-patológicos de neoplasias papilares intraductales pancreáticas con diferentes fenotipos y evolución.

Pérez Rojas J, Artes MJ, Prieto Rodríguez M, Moya Herraiz AA, Guarín Corredor MJ, López Valdivia C, Vera Sempere JF GASTROENT HEPAT-BARC (38) 71-74.
[doi:10.1016/j.gastrohep.2014.03.015]

TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency.

Fernández-Álvarez S, Gutiérrez-de Juan V, Zubiete-Franco I, Barbier-Torres L, Lahoz A, Parés A, Luka Z, Wagner C, Lu SC, Mato JM, Martínez-Chantar ML, Beraza N LAB INVEST (95) 223-236.
[doi:10.1038/labinvest.2014.151]

Review of the treatment of liver hydatid cysts.

Gomez I Gavara C, López-Andújar R, Belda Ibáñez T, Ramia Ángel JM, Moya Herraiz Á, Orbis Castellanos F, Pareja Ibars E, San Juan Rodríguez F WORLD J GASTROENTERO (21) 124-131.
[doi:10.3748/wjg.v21.i1.124]

In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4a expression.

Sangan CB, Jover R, Heimberg H, Tosh D MOL CELL ENDOCRINOL (399) 50-59.
[doi:10.1016/j.mce.2014.09.009]

A score model for the continuous grading of early allograft dysfunction severity.

Pareja E, Cortes M, Hervás D, Mir J, Valdivieso A, Castell JV, Lahoz A LIVER TRANSPLANT (21) 38-46.
[doi:10.1002/lt.23990]

Entecavir has high efficacy and safety in white patients with chronic hepatitis B and comorbidities.

Buti M, Morillas RM, Pérez J, Prieto M, Solà R, Palau A, Diago M, Bonet L, Gallego A, García-Samaniego J, Testillano M, Rodríguez M, Castellano G, Gutiérrez ML, Delgado M, Mas A, Romero-Gómez M, Calleja JL, González-Guirado A, Arenas JI, García-Buey L, Andrade R, Gila A, ORIENTE-2 study group EUR J GASTROEN HEPAT (27) 46-54.
[doi:10.1097/MEG.0000000000000195]

Immunohistochemical, genetic and epigenetic profiles of hereditary and triple negative breast cancers. Relevance in personalized medicine.

Murria R, Palanca S, de Juan I, Alenda C, Egoavil C, Seguí FJ, García-Casado Z, Juan MJ, Sánchez AB, Segura Á, Santaballa A, Chirivella I, Llop M, Pérez G, Barragán E, Salas D, Bolufer P American Journal of Cancer Research (5) 2330-2343.

Transfusion management and immunohematologic complications in liver transplantation: experience of a single institution.

Solves P, Carpio N, Moscardo F, Lancharro A, Cano I, Moya A, López-Andujar R, Sanz MÁ TRANSFUS MED HEMOTH (42) 8-14.
[doi:10.1159/000370260]

Distinct phenotype of hepatotoxicity associated with illicit use of anabolic androgenic steroids.

Robles-Diaz M, Gonzalez-Jimenez A, Medina-Caliz I, Stephens C, García-Cortes M, García-Muñoz B, Ortega-Alonso A, Blanco-Reina E, Gonzalez-Grande R, Jimenez-Perez M, Rendón P, Navarro JM, Gines P, Prieto M, Garcia-Eliz M, Bessone F, Brahm JR, Paraná R, Lucena MI, Andrade RJ, Spanish DILI Registry, SLatinDILI Network ALIMENT PHARM THER (41) 116-125.
[doi:10.1111/apt.13023]

Pegylated interferon plus ribavirin in HIV-infected patients with recurrent hepatitis C after liver transplantation: a prospective cohort study.

Castells L, Rimola A, Manzardo C, Valdivieso A, Montero JL, Barcena R, Abradelo M, Xiol X, Aguilera V, Salcedo M, Rodriguez M, Bernal C, Suarez F, Antela A, Olivares S, Del Campo S, Laguno M, Fernandez JR, de la Rosa G, Agüero F, Perez I, González-García J, Esteban-Mur JI, Miro JM, FIPSE LT-HIV Investigators J HEPATOL (62) 92-100.
[doi:10.1016/j.jhep.2014.07.034]

Transfection of Primary Hepatocytes with Liver-Enriched Transcription Factors Using Adenoviral Vectors.

Benet M, Jover R, Bort R Methods in molecular biology (Clifton, N.J.) (1250) 213-221.
[doi:10.1007/978-1-4939-2074-7_15]

Update on the diagnosis and treatment of mirizzi syndrome in laparoscopic era: our experience in 7 years.

Lledó JB, Barber SM, Ibañez JC, Torregrosa AG, Lopez-Andujar R SURG LAPARO ENDO PER (24) 495-501.
[doi:10.1097/SLE.0000000000000079]

Diaphragmatic hernia after liver transplantation in children: case series and review of the literature.

Cortes M, Tapuria N, Khorsandi SE, Ibars EP, Vilca-Melendez H, Rela M, Heaton ND LIVER TRANSPLANT (20) 1429-1435.
[doi:10.1002/lt.23977]

[Giant hepatic artery aneurysm: Management of an infrequent entity].

Pareja E, Barber S, Montes H, Arango J, Lloret M GASTROENT HEPAT-BARC (37) 567-570.
[doi:10.1016/j.gastrohep.2014.03.006]

Competency of different cell models to predict human hepatotoxic drugs.

Gómez-Lechón MJ, Tolosa L, Conde I, Donato MT EXPERT OPIN DRUG MET (10) 1553-1568.
[doi:10.1517/17425255.2014.967680]

[Design of a preoperative predictive score for choledocholithiasis].

Bueno Lledó J, Ibáñez Cirión JL, Torregrosa Gallud A, López Andújar R GASTROENT HEPAT-BARC (37) 511-518.
[doi:10.1016/j.gastrohep.2014.04.001]

Use of artificial intelligence as an innovative donor-recipient matching model for liver transplantation: results from a multicenter Spanish study.

Briceño J, Cruz-Ramírez M, Prieto M, Navasa M, Ortiz de Urbina J, Orti R, Gómez-Bravo MÁ, Otero A, Varo E, Tomé S, Clemente G, Bañares R, Bárcena R, Cuervas-Mons V, Solórzano G, Vinaixa C, Rubín A, Colmenero J, Valdivieso A, Ciria R, Hervás-Martínez C, de la Mata M J HEPATOL (61) 1020-1028.
[doi:10.1016/j.jhep.2014.05.039]

Apicobasal polarity controls lymphocyte adhesion to hepatic epithelial cells.

Reglero-Real N, Alvarez-Varela A, Cernuda-Morollón E, Feito J, Marcos-Ramiro B, Fernández-Martín L, Gómez-Lechón MJ, Muntané J, Sandoval P, Majano PL, Correas I, Alonso MA, Millán J Cell Reports (8) 1879-1893.
[doi:10.1016/j.celrep.2014.08.007]

Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices.

Jetten MJ, Claessen SM, Dejong CH, Lahoz A, Castell JV, van Delft JH, Kleinjans JC Toxicology (323) 61-69.
[doi:10.1016/j.tox.2014.06.007]

Metabolomics discloses donor liver biomarkers associated with early allograft dysfunction.

Cortes M, Pareja E, García-Cañaveras JC, Donato MT, Montero S, Mir J, Castell JV, Lahoz A J HEPATOL (61) 564-574.
[doi:10.1016/j.jhep.2014.04.023]

A score model for the continuous grading of early allograft dysfunction severity.

Pareja E, Cortes M, Hervás D, Mir J, Valdivieso A, Castell JV, Lahoz A Liver Transplantation -.

Pharmacological profiles of acute myeloid leukemia treatments in patient samples by automated flow cytometry: a bridge to individualized medicine.

Bennett TA, Montesinos P, Moscardo F, Martinez-Cuadron D, Martinez J, Sierra J, García R, de Oteyza JP, Fernandez P, Serrano J, Fernandez A, Herrera P, Gonzalez A, Bethancourt C, Rodriguez-Macias G, Alonso A, Vera JA, Navas B, Lavilla E, Lopez JA, Jimenez S, Simiele A, Vidriales B, Gonzalez BJ, Burgaleta C, Hernandez Rivas JA, Mascuñano RC, Bautista G, Perez Simon JA, Fuente Ade L, Rayón C, Troconiz IF, Janda A, Bosanquet AG, Hernandez-Campo P, Primo D, Lopez R, Liebana B, Rojas JL, Gorrochategui J, Sanz MA, Ballesteros J Clinical lymphoma, myeloma & leukemia (14) 305-318.
[doi:10.1016/j.clml.2013.11.006]

Low RNA translation activit limits the efficacy of hydrodynamic gene transfer to pig liver in vivo.

Sendra L, Carreño O, Miguel A, Montalvá E, Herrero MJ, Orbis F, Noguera I, Barettino D, López-Andújar R, Aliño SF J GENE MED (16) 179-192.
[doi:10.1002/jgm.2777]

Estrategias para evitar la recidiva viral B después del trasplante hepático.

Prieto M, García-Eliz M GASTROENT HEPAT-BARC (37 Suppl 2) 30-42.
[doi:10.1016/S0210-5705(14)70067-6]

Use of Hy's law and a new composite algorithm to predict acute liver failure in patients with drug-induced liver injury.

Robles-Diaz M, Lucena MI, Kaplowitz N, Stephens C, Medina-Cáliz I, González-Jimenez A, Ulzurrun E, Gonzalez AF, Fernandez MC, Romero-Gómez M, Jimenez-Perez M, Bruguera M, Prieto M, Bessone F, Hernandez N, Arrese M, Andrade RJ, Spanish DILI Registry, SLatinDILI Network, Safer and Faster Evidence-based Translation Consortium Gastroenterology (147) 109-118.e5-.
[doi:10.1053/j.gastro.2014.03.050]

Control of Diabetes Mellitus in Liver Transplant Recipients

Ramos-Prol, Agustin, Rodriguez-Medina, Beatriz, Herrero, Ignacio, Serrano, Trinidad, De la Mata, Manuel, Rubin, Angel, Prieto, Martin, Berenguer, Marina, Francisco Merino-Torres, Juan Diabetes (63) -.

Intrahepatic cholangiocarcinoma or mixed hepatocellular-cholangiocarcinoma in patients undergoing liver transplantation: a Spanish matched cohort multicenter study.

Sapisochin G, de Lope CR, Gastaca M, de Urbina JO, López-Andujar R, Palacios F, Ramos E, Fabregat J, Castroagudín JF, Varo E, Pons JA, Parrilla P, González-Diéguez ML, Rodriguez M, Otero A, Vazquez MA, Zozaya G, Herrero JI, Antolin GS, Perez B, Ciria R, Rufian S, Fundora Y, Ferron JA, Guiberteau A, Blanco G, Varona MA, Barrera MA, Suarez MA, Santoyo J, Bruix J, Charco R ANN SURG (259) 944-952.
[doi:10.1097/SLA.0000000000000494]

Genotype and allele frequencies of drug-metabolizing enzymes and drug transporter genes affecting immunosuppressants in the Spanish white population.

Bosó V, Herrero MJ, Buso E, Galán J, Almenar L, Sánchez-Lázaro I, Sánchez-Plumed J, Bea S, Prieto M, García M, Pastor A, Sole A, Poveda JL, Aliño SF THER DRUG MONIT (36) 159-168.
[doi:10.1097/FTD.0b013e3182a94e65]

A simple transcriptomic signature able to predict drug-induced hepatic steatosis.

Benet M, Moya M, Donato MT, Lahoz A, Hervás D, Guzmán C, Gómez-Lechón MJ, Castell JV, Jover R ARCH TOXICOL (88) 967-982.
[doi:10.1007/s00204-014-1197-7]

The impact of the prevention strategies on the indirect effects of CMV infection in solid organ transplant recipients.

Roman A, Manito N, Campistol JM, Cuervas-Mons V, Almenar L, Arias M, Casafont F, del Castillo D, Crespo-Leiro MG, Delgado JF, Herrero JI, Jara P, Morales JM, Navarro M, Oppenheimer F, Prieto M, Pulpón LA, Rimola A, Serón D, Ussetti P, ATOS working group Transplantation Reviews (28) 84-91.
[doi:10.1016/j.trre.2014.01.001]

[Hepatic adenomatosis: a disease with controversial treatment].

Lucas E, Pareja E, Carvajal N, Pacheco A, Moya A CIR ESPAN (92) 284-286.
[doi:10.1016/j.ciresp.2013.09.006]

Modulation of PI3K-LXRa-dependent lipogenesis mediated by oxidative/nitrosative stress contributes to inhibition of HCV replication by quercetin.

Pisonero-Vaquero S, García-Mediavilla MV, Jorquera F, Majano PL, Benet M, Jover R, González-Gallego J, Sánchez-Campos S LAB INVEST (94) 262-274.
[doi:10.1038/labinvest.2013.156]

"Very early" intrahepatic cholangiocarcinoma in cirrhotic patients: should liver transplantation be reconsidered in these patients?

Sapisochin G, Rodríguez de Lope C, Gastaca M, Ortiz de Urbina J, Suarez MA, Santoyo J, Castroagudín JF, Varo E, López-Andujar R, Palacios F, Sanchez Antolín G, Perez B, Guiberteau A, Blanco G, González-Diéguez ML, Rodriguez M, Varona MA, Barrera MA, Fundora Y, Ferron JA, Ramos E, Fabregat J, Ciria R, Rufian S, Otero A, Vazquez MA, Pons JA, Parrilla P, Zozaya G, Herrero JI, Charco R, Bruix J AM J TRANSPLANT (14) 660-667.
[doi:10.1111/ajt.12591]

[Hepatic endometrioma. An update and new approaches].

Cantos Pallarés M, López Andújar R, Montalvá Orón EM, Castillo Ferrer MC, Rayón Martín M CIR ESPAN (92) 212-214.
[doi:10.1016/j.ciresp.2012.01.014]

Estado actual y perspectivas futuras del trasplante de hepatocitos.

Pareja E, Cortés M, Gómez-Lechón MJ, Maupoey J, San Juan F, López R, Mir J CIR ESPAN (92) 74-81.
[doi:10.1016/j.ciresp.2013.04.010]

Ultra-performance liquid chromatography-mass spectrometry targeted profiling of bile acids: application to serum, liver tissue, and cultured cells of different species.

García-Cañaveras JC, Donato MT, Lahoz A Methods in molecular biology (Clifton, N.J.) (1198) 233-247.
[doi:10.1007/978-1-4939-1258-2_15]

Anaphylaxis due to pentoxifylline.

Carballada F, Guitián L, Nuñez R, Lopez R, Pineda F, Boquete M J INVEST ALLERG CLIN (24) 457-458.

Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture.

Gieseck RL, Hannan NR, Bort R, Hanley NA, Drake RA, Cameron GW, Wynn TA, Vallier L Plos One (9) e86372-.
[doi:10.1371/journal.pone.0086372]

Testing chemical carcinogenicity by using a transcriptomics HepaRG-based model?

Doktorova TY, Yildirimman R, Ceelen L, Vilardell M, Vanhaecke T, Vinken M, Ates G, Heymans A, Gmuender H, Bort R, Corvi R, Phrakonkham P, Li R, Mouchet N, Chesne C, van Delft J, Kleinjans J, Castell J, Herwig R, Rogiers V EXCLI J (13) 623-637.

Liver transplantation for bile duct injury after open and laparoscopic cholecystectomy.

Parrilla P, Robles R, Varo E, Jiménez C, Sánchez-Cabús S, Pareja E, Spanish Liver Transplantation Study Group BRIT J SURG (101) 63-68.
[doi:10.1002/bjs.9349]

Neonatal livers: a source for the isolation of good-performing hepatocytes for cell transplantation.

Tolosa L, Pareja-Ibars E, Donato MT, Cortés M, López S, Jiménez N, Mir J, Castell JV, Gómez-Lechón MJ CELL TRANSPLANT (23) 1229-1242.
[doi:10.3727/096368913X669743]

Improved renal function in liver transplant recipients treated for hepatitis C virus with a sustained virological response and mild chronic kidney disease.

Blé M, Aguilera V, Rubín A, García-Eliz M, Vinaixa C, Prieto M, Berenguer M LIVER TRANSPLANT (20) 25-34.
[doi:10.1002/lt.23756]

A simple transcriptomic signature able to predict drug-induced hepatic steatosis.

Benet M, Moya M, Donato MT, Lahoz A, Hervás D, Guzmán C, Gómez-Lechón MJ, Castell JV, Jover R Archives of toxicology -.

Protease inhibitors impair renal function in HCV-infected immunocompetent patients

Fernandez-Carrillo, Carlos, Manuel Pascasio, Juan, Prieto, Martin, Montero, J. L., Crespo, Javier, Fernandez, Inmaculada, Forns, Xavier, Garcia-Samaniego, Javier, Romero-Gomez, Manuel, Turnes, Juan, Javier Moreno, J., Llop, Elba, Serrano-Millan, Cristina, Buti, Maria, Luis Calleja, Jose Hepatology (60) 679-679.

National Consensus on the Diagnosis, Risk Stratification and Treatment of Patients with Pulmonary Embolism. Spanish Society of Pneumology and Thoracic Surgery (SEPAR). Society Española Internal Medicine (SEMI). Spanish Society of Thrombosis and Haemostasis (SETH). Spanish Society of Cardiology (ESC). Spanish Society of Medicine Accident and Emergency (SEMES). Spanish Society of Angiology and Surgery Vascular (SEACV).

Uresandi F, Monreal M, García-Bragado F, Domenech P, Lecumberri R, Escribano P, Zamorano JL, Jiménez S, Ruiz-Artacho P, Lozano F, Romera A, Jiménez D, National Consensus on Diagnosis, Risk Stratification and Treatment of Patients W, Bellmunt S, Cuenca J, Fernández Á, Fernández F, Ibáñez V, Lozano F, March JR, Romera A, Almenar L, Castro A, Escribano P, Lázaro M, Luis Zamorano J, Alonso JR, Ramón Casal J, Miguel Franco J, Jiménez S, Merlo M, Perales R, Piñera P, Ruiz-Artacho P, Suero C, Barba R, Fernández-Capitán C, García-Bragado F, Gómez V, Monreal M, Nieto JA, Riera-Mestre A, Suárez C, Trujillo-Santos J, Conget F, Jara L, Jiménez D, Lobo JL, de Miguel J, Nauffal D, Oribe M, Otero R, Uresandi F, Domenech P, González-Porras JR, Lecumberri R, Llamas P, Mingot E, Pina E, Rodríguez-Martorell J, : Spanish Society of Pneumology and Thoracic Surgery (SEPAR), Society Española Internal Medicine (SEMI), Spanish Society of Thrombosis and Haemostasis (SETH), Spanish Society of Cardiology (ESC), Spanish Society of Medicine Accident and Emergency (SEMES), Spanish Society of Angiology and Surgery Vascular (SEACV) ARCH BRONCONEUMOL (49) 534-547.
[doi:10.1016/j.arbres.2013.07.008]

Instability of the faecal microbiota in diarrhoea-predominant irritable bowel syndrome.

Durbán A, Abellán JJ, Jiménez-Hernández N, Artacho A, Garrigues V, Ortiz V, Ponce J, Latorre A, Moya A FEMS MICROBIOL ECOL (86) 581-589.
[doi:10.1111/1574-6941.12184]

[Liver cell therapy in the treatment of inborn errors of metabolism in children].

Pareja E, Ribes C, Gómez-Lechón MJ, Cortes M, Vila JJ, Dalmau J, Ibáñez V, Polo B, Castell JV, Mir J AN PEDIATR (79) 390.e1-8-.
[doi:10.1016/j.anpedi.2013.05.018]

Validation Of a Comprehensive Health Status Assessment Scale In Older Patients (>= 65 years) With Hematological Malignances. Gah Study

Bonanad, Santiago, Persona, Ernesto Perez, Oiartzabal, Itziar, Gonzalez, Bernardo, Fernandez-Lago, Carlos, Zudaire, Maria Teresa, Gironella, Mercedes, Soler, Alfonso, Valcarcel, David, Hernandez-Rivas, Jose Angel, Marrero, Carmen, Arnan, Montserrat, Olivier, Carmen, Abrisqueta, Pau, Xicoy, Blanca, Sarra, Josep, Nomdedeu, Benet, Gonzalez, Eva, Martinez, Jesus, Gonzalez-Campos, Jose, Encinas, Cristina, Laiglesia, Almudena, Fernandez-Maqueda, Cristina, Jarque, Isidro, Ferra, Christelle, Falantes, Jose, Carrillo, Estrella, Munoz, Cristina, Feliu, J., Duran, Marta, Marcos, Marina, Lopez, Silvia, Cruz-Jentoft, Alfonso J., De La Rubia, Javier Blood (122) -.

Hepatic cell lines for drug hepatotoxicity testing: limitations and strategies to upgrade their metabolic competence by gene engineering.

Donato MT, Jover R, Gómez-Lechón MJ CURR DRUG METAB (14) 946-968.

Haemophagocytic syndrome in a liver transplant patient during treatment with Telaprevir.

Rodríguez-Medina B, Blanes M, Vinaixa C, Aguilera V, Rubín A, Prieto M, Berenguer M ANN HEPATOL (12) 974-978.

Mammalian cell metabolomics: experimental design and sample preparation.

León Z, García-Cañaveras JC, Donato MT, Lahoz A Electrophoresis (34) 2762-2775.
[doi:10.1002/elps.201200605]

Hepatolitiasis simulando un colangiocarcinoma hiliar.

Vergara Suárez F, López Andújar R, Montalvá Orón E, Ramírez Ribelles C, Pérez Rojas J CIR ESPAN (91) 535-537.
[doi:10.1016/j.ciresp.2013.03.003]

Estimation of the elastic parameters of human liver biomechanical models by means of medical images and evolutionary computation.

Martínez-Martínez F, Rupérez MJ, Martín-Guerrero JD, Monserrat C, Lago MA, Pareja E, Brugger S, López-Andújar R COMPUT METH PROG BIO (111) 537-549.
[doi:10.1016/j.cmpb.2013.05.005]

[Availability of resources for patients with wet age-related macular degeneration. Optimal study].

Casaroli-Marano R, Roura M, Grupo de Estudio Optimal Archivos de la Sociedad Espanola de Oftalmologia (88) 307-312.
[doi:10.1016/j.oftal.2012.10.009]

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gómez-Lechón MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Häussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhütter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stöber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG ARCH TOXICOL (87) 1315-1530.
[doi:10.1007/s00204-013-1078-5]

Inhibition of VEGF expression through blockade of Hif1a and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.

Carbajo-Pescador S, Ordoñez R, Benet M, Jover R, García-Palomo A, Mauriz JL, González-Gallego J BRIT J CANCER (109) 83-91.
[doi:10.1038/bjc.2013.285]

Multiparametric evaluation of the cytoprotective effect of the Mangifera indica L. stem bark extract and mangiferin in HepG2 cells.

Tolosa L, Rodeiro I, Donato MT, Herrera JA, Delgado R, Castell JV, Gómez-Lechón MJ J PHARM PHARMACOL (65) 1073-1082.
[doi:10.1111/jphp.12071]

Long-term outcome of 'long-term liver transplant survivors'.

Rubín A, Sánchez-Montes C, Aguilera V, Juan FS, Ferrer I, Moya A, Montalva E, Pareja E, López-Andujar R, Prieto M, Berenguer M TRANSPL INT (26) 740-750.
[doi:10.1111/tri.12118]

T-tube or no T-tube in cadaveric orthotopic liver transplantation: the eternal dilemma: results of a prospective and randomized clinical trial.

López-Andújar R, Orón EM, Carregnato AF, Suárez FV, Herraiz AM, Rodríguez FS, Carbó JJ, Ibars EP, Sos JE, Suárez AR, Castillo MP, Pallardó JM, De Juan Burgueño M ANN SURG (258) 21-29.
[doi:10.1097/SLA.0b013e318286e0a0]

A combination of transcriptomics and metabolomics uncovers enhanced bile acid biosynthesis in HepG2 cells expressing CCAAT/enhancer-binding protein ß (C/EBPß), hepatocyte nuclear factor 4a (HNF4a), and constitutive androstane receptor (CAR).

Blazquez M, Carretero A, Ellis JK, Athersuch TJ, Cavill R, Ebbels TM, Keun HC, Castell JV, Lahoz A, Bort R J PROTEOME RES (12) 2732-2741.
[doi:10.1021/pr400085n]

HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved.

Tolosa L, Gómez-Lechón MJ, Pérez-Cataldo G, Castell JV, Donato MT ARCH TOXICOL (87) 1115-1127.
[doi:10.1007/s00204-013-1012-x]

Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models.

Doktorova TY, Yildirimman R, Vinken M, Vilardell M, Vanhaecke T, Gmuender H, Bort R, Brolen G, Holmgren G, Li R, Chesne C, van Delft J, Kleinjans J, Castell J, Bjorquist P, Herwig R, Rogiers V Carcinogenesis (34) 1393-1402.
[doi:10.1093/carcin/bgt054]

Comparative analysis of eight cytotoxicity assays evaluated within the ACuteTox Project.

Clothier R, Gómez-Lechón MJ, Kinsner-Ovaskainen A, Kopp-Schneider A, O'Connor JE, Prieto P, Stanzel S TOXICOL IN VITRO (27) 1347-1356.
[doi:10.1016/j.tiv.2012.08.015]

An in vitro tool to assess cytochrome P450 drug biotransformation-dependent cytotoxicity in engineered HepG2 cells generated by using adenoviral vectors.

Lahoz A, Vilà MR, Fabre M, Miquel JM, Rivas M, Maines J, Castell JV, Gómez-Lechón MJ TOXICOL IN VITRO (27) 1410-1415.
[doi:10.1016/j.tiv.2012.08.001]

Chronic kidney disease after liver transplantation: pretransplantation risk factors and predictors during follow-up.

Giusto M, Berenguer M, Merkel C, Aguilera V, Rubin A, Ginanni Corradini S, Mennini G, Rossi M, Prieto M, Merli M Transplantation (95) 1148-1153.
[doi:10.1097/TP.0b013e3182884890]

Mangifera indica L. extract and mangiferin modulate cytochrome P450 and UDP-glucuronosyltransferase enzymes in primary cultures of human hepatocytes.

Rodeiro I, José Gómez-Lechón M, Perez G, Hernandez I, Herrera JA, Delgado R, Castell JV, Teresa Donato M PHYTOTHER RES (27) 745-752.
[doi:10.1002/ptr.4782]

The human liver fatty acid binding protein (FABP1) gene is activated by FOXA1 and PPARa; and repressed by C/EBPa: Implications in FABP1 down-regulation in nonalcoholic fatty liver disease.

Guzmán C, Benet M, Pisonero-Vaquero S, Moya M, García-Mediavilla MV, Martínez-Chantar ML, González-Gallego J, Castell JV, Sánchez-Campos S, Jover R Biochimica et biophysica acta (1831) 803-818.
[doi:10.1016/j.bbalip.2012.12.014]

Comparison of results of combined liver-kidney transplantation vs. isolated liver transplantation.

Aguilera V, Ferrer I, Berenguer M, Rivera J, Rubín Á, Moya Á, Pareja E, Sánchez J, Prieto M, Mir J ANN HEPATOL (12) 274-281.

Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: a quantitative method for oxidative stress assessment of nanoparticle-treated cells.

Aranda A, Sequedo L, Tolosa L, Quintas G, Burello E, Castell JV, Gombau L TOXICOL IN VITRO (27) 954-963.
[doi:10.1016/j.tiv.2013.01.016]

miR-133a regulates vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1), a key protein in the vitamin K cycle.

Pérez-Andreu V, Teruel R, Corral J, Roldán V, García-Barberá N, Salloum-Asfar S, Gómez-Lechón MJ, Bourgeois S, Deloukas P, Wadelius M, Vicente V, González-Conejero R, Martínez C MOL MED (18) 1466-1472.
[doi:10.2119/molmed.2012.00062]

A surgical model for isolating the pig liver in vivo for gene therapy.

Carreño O, Sendra L, Montalvá E, Miguel A, Orbis F, Herrero MJ, Noguera I, Aliño SF, Lopez-Andujar R EUR SURG RES (51) 47-57.
[doi:10.1159/000351339]

False positive rate of an arrayCGH platform for single-cell preimplantation genetic screening and subsequent clinical application on day-3.

Mir P, Rodrigo L, Mercader A, Buendía P, Mateu E, Milán-Sánchez M, Peinado V, Pellicer A, Remohí J, Simón C, Rubio C J ASSIST REPROD GEN (30) 143-149.
[doi:10.1007/s10815-012-9918-4]

Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4a upregulation in primary human hepatocytes.

Rulcova A, Krausova L, Smutny T, Vrzal R, Dvorak Z, Jover R, Pavek P PHARMACOL REP (65) 1322-1335.

Cellular and molecular mechanisms involved in the neuroprotective effects of VEGF on motoneurons.

Lladó J, Tolosa L, Olmos G FRONT CELL NEUROSCI (7) 181-181.
[doi:10.3389/fncel.2013.00181]

Human hepatocyte transplantation in patients with hepatic failure awaiting a graft.

Pareja E, Gomez-Lechon MJ, Cortes M, Bonora-Centelles A, Castell JV, Mir J EUR SURG RES (50) 273-281.
[doi:10.1159/000351332]

Gata4 blocks somatic cell reprogramming by directly repressing Nanog.

Serrano F, Calatayud CF, Blazquez M, Torres J, Castell JV, Bort R Stem Cells (31) 71-82.
[doi:10.1002/stem.1272]

Efficacy of the retreatment of hepatitis C virus infections after liver transplantation: role of an aggressive approach.

Berenguer M, Roche B, Aguilera V, Duclos-Vallée JC, Navarro L, Rubín A, Pons JA, de la Mata M, Prieto M, Samuel D LIVER TRANSPLANT (19) 69-77.
[doi:10.1002/lt.23555]

Efficacy of the retreatment of hepatitis C virus infections after liver transplantation: Role of an aggressive approach

Berenguer, Marina, Roche, Bruno, Aguilera, Victoria, Duclos-Vallee, Jean-Charles, Navarro, Laia, Rubin, Angel, Pons, Jose-Antonio, de la Mata, Manuel, Prieto, Martin, Samuel, Didier LIVER TRANSPLANT (19) 69-77.

Upgrading cytochrome P450 activity in HepG2 cells co-transfected with adenoviral vectors for drug hepatotoxicity assessment.

Tolosa L, Donato MT, Pérez-Cataldo G, Castell JV, Gómez-Lechón MJ TOXICOL IN VITRO (26) 1272-1277.
[doi:10.1016/j.tiv.2011.11.008]

Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method.

García-Cañaveras JC, Donato MT, Castell JV, Lahoz A J LIPID RES (53) 2231-2241.
[doi:10.1194/jlr.D028803]

Drug-induced liver steatosis and phospholipidosis: cell-based assays for early screening of drug candidates.

Donato MT, Gómez-Lechón MJ CURR DRUG METAB (13) 1160-1173.

Evaluation of genotoxicity and DNA protective effects of mangiferin, a glucosylxanthone isolated from Mangifera indica L. stem bark extract.

Rodeiro I, Hernandez S, Morffi J, Herrera JA, Gómez-Lechón MJ, Delgado R, Espinosa-Aguirre JJ FOOD CHEM TOXICOL (50) 3360-3366.
[doi:10.1016/j.fct.2012.06.032]

Recurrent testicular germ cell tumors in a family with MYH-associated polyposis.

Castillejo A, Sanchez-Heras AB, Jover R, Castillejo MI, Guarinos C, Oltra S, Martínez-Canto A, Barbera VM, Laforga J, Paya A, Alenda C, Soto JL J CLIN ONCOL (30) e216-7-.
[doi:10.1200/JCO.2012.41.5992]

Synthesis and cytotoxic activity of 4-N-carboxybutyl-5-fluorocytosyl-Arg-Gln-Trp-Arg-Arg-Trp-Trp-Gln-Arg-NH2.

Somlai C, Correche E, Olivella M, Tolosa L, Lechon MJ, Dombi G, Tóth GK, Penke B, Enriz RD BIOORG MED CHEM LETT (22) 4233-4237.
[doi:10.1016/j.bmcl.2012.05.045]

Measurement of asthma control according to Global Initiative for Asthma guidelines: a comparison with the Asthma Control Questionnaire.

Olaguibel JM, Quirce S, Juliá B, Fernández C, Fortuna AM, Molina J, Plaza V, MAGIC Study Group RESP RES (13) 50-50.
[doi:10.1186/1465-9921-13-50]

Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs.

Tolosa L, Pinto S, Donato MT, Lahoz A, Castell JV, O'Connor JE, Gómez-Lechón MJ Toxicological sciences : an official journal of the Society of Toxicology (127) 187-198.
[doi:10.1093/toxsci/kfs083]

Pain in clinical oncology: patient satisfaction with management of cancer pain.

Antón A, Montalar J, Carulla J, Jara C, Batista N, Camps C, Cassinello J, Sanz-Ortiz J, Díaz-Rubio E, Martínez C, Ledesma F, Zubillaga E, ALGOS Group, DOME III Study Group EUR J PAIN (16) 381-389.
[doi:10.1002/j.1532-2149.2011.00036.x]

High-content imaging technology for the evaluation of drug-induced steatosis using a multiparametric cell-based assay.

Donato MT, Tolosa L, Jiménez N, Castell JV, Gómez-Lechón MJ J BIOMOL SCREEN (17) 394-400.
[doi:10.1177/1087057111427586]

Could clinical scores guide the surgical treatment of necrotizing enterocolitis?

Ibáñez V, Couselo M, Marijuán V, Vila JJ, García-Sala C PEDIATR SURG INT (28) 271-276.
[doi:10.1007/s00383-011-3016-z]

Evaluation of cytochrome P450 activities in human hepatocytes in vitro.

Gómez-Lechón MJ, Lahoz A, Castell JV, Donato MT Methods in molecular biology (Clifton, N.J.) (806) 87-97.
[doi:10.1007/978-1-61779-367-7_7]

Clinical outcome of hepatocyte transplantation in four pediatric patients with inherited metabolic diseases.

Ribes-Koninckx C, Ibars EP, Calzado Agrasot MÁ, Bonora-Centelles A, Miquel BP, Vila Carbó JJ, Aliaga ED, Pallardó JM, Gómez-Lechón MJ, Castell JV CELL TRANSPLANT (21) 2267-2282.
[doi:10.3727/096368912X637505]

Foxa1 reduces lipid accumulation in human hepatocytes and is down-regulated in nonalcoholic fatty liver.

Moya M, Benet M, Guzmán C, Tolosa L, García-Monzón C, Pareja E, Castell JV, Jover R Plos One (7) e30014-.
[doi:10.1371/journal.pone.0030014]

Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London.

Puppi J, Strom SC, Hughes RD, Bansal S, Castell JV, Dagher I, Ellis EC, Nowak G, Ericzon BG, Fox IJ, Gómez-Lechón MJ, Guha C, Gupta S, Mitry RR, Ohashi K, Ott M, Reid LM, Roy-Chowdhury J, Sokal E, Weber A, Dhawan A CELL TRANSPLANT (21) 1-10.
[doi:10.3727/096368911X566208]

Anemia is Not Predictive of Sustained Virological Response in Liver Transplant Recipients with Hepatitis C Virus Who are Treated with Pegylated Interferon and Ribavirin

Giusto, Michela, Rodriguez, Maria, Navarro, Laia, Rubin, Angel, Aguilera, Victoria, San-Juan, Fernando, Ortiz, Cecilia, Lopez-Andujar, Rafael, Prieto, Martin, Berenguer, Marina LIVER TRANSPLANT (17) 1318-1327.

Genome economization in the endosymbiont of the wood roach Cryptocercus punctulatus due to drastic loss of amino acid synthesis capabilities.

Neef A, Latorre A, Peretó J, Silva FJ, Pignatelli M, Moya A GENOME BIOL EVOL (3) 1437-1448.
[doi:10.1093/gbe/evr118]

Effect of Calcineurin Inhibitors in the Outcome of Liver Transplantation in Hepatitis C Virus-Positive Recipients

Berenguer, Marina, Aguilera, Victoria, San Juan, Fernando, Benlloch, Salvador, Rubin, Angel, Lopez-Andujar, Rafael, Moya, Angel, Pareja, Eugenia, Montalva, Eva, Yago, Maria, de Juan, Manuel, Mir, Jose, Prieto, Martin Transplantation (90) 1204-1209.

Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage.

Alfonso-Loeches S, Pascual-Lucas M, Blanco AM, Sanchez-Vera I, Guerri C J NEUROSCI (30) 8285-8295.
[doi:10.1523/JNEUROSCI.0976-10.2010]

Indications and results of liver retransplantation: experience with 1181 patients in the hospital universitario La Fe

Torres-Queuedo, Rodrigo, Moya-Herraiz, Angel, San Juan, Fernando, Rivera, Jairo, Lopez-Andujar, Rafael, Montalva, Eva, Pareja, Eugenia, De Juan, Manuel, Aguilera, Victoria, Berenguer, Marina, Prieto, Martin, Mir, Jose CIR ESPAN (87) 356-363.

Interaction between Hhex and SOX13 modulates Wnt/TCF activity.

Marfil V, Moya M, Pierreux CE, Castell JV, Lemaigre FP, Real FX, Bort R J BIOL CHEM (285) 5726-5737.
[doi:10.1074/jbc.M109.046649]

Influence of peritoneal fluid on the expression of angiogenic and proteolytic factors in cultures of endometrial cells from women with endometriosis.

Cosín R, Gilabert-Estellés J, Ramón LA, Gómez-Lechón MJ, Gilabert J, Chirivella M, Braza-Boïls A, España F, Estellés A HUMAN REPRODUCTION (25) 398-405.
[doi:10.1093/humrep/dep419]

Comparative Prospective Study of Two Liver Graft Preservation Solutions: University of Wisconsin and Celsior

Lopez-Andujar, Rafael, Deusa, Saulo, Montalva, Eva, Juan, Fernando San, Moya, Angel, Pareja, Eugenia, DeJuan, Manuel, Berenguer, Marina, Prieto, Martin, Mir, Jose LIVER TRANSPLANT (15) 1709-1717.

Evolutionary convergence and nitrogen metabolism in Blattabacterium strain Bge, primary endosymbiont of the cockroach Blattella germanica.

López-Sánchez MJ, Neef A, Peretó J, Patiño-Navarrete R, Pignatelli M, Latorre A, Moya A PLOS GENET (5) e1000721-.
[doi:10.1371/journal.pgen.1000721]

Cirrhosis of Mixed Etiology (Hepatitis C Virus and Alcohol): Posttransplantation Outcome-Comparison with Hepatitis C Virus-Related Cirrhosis and Alcoholic-Related Cirrhosis

Aguilera, Victoria, Berenguer, Marina, Rubin, Angel, San-Juan, Fernando, Rayon, Jose-Miguel, Prieto, Martin, Mir, Jose LIVER TRANSPLANT (15) 79-87.

Expanded criteria for liver transplantation in patients with cirrhosis and hepatocellular carcinoma

Silva, Mauricio, Moya, Angel, Berenguer, Marina, Sanjuan, Fernando, Lopez-Andujar, Rafael, Pareja, Eugenia, Torres-Quevedo, Rodrigo, Aguilera, Victoria, Montalva, Eva, De Juan, Manuel, Mattos, Angelo, Prieto, Martin, Mir, Jose LIVER TRANSPLANT (14) 1449-1460.

The carcinoGENOMICS project: critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays.

Vinken M, Doktorova T, Ellinger-Ziegelbauer H, Ahr HJ, Lock E, Carmichael P, Roggen E, van Delft J, Kleinjans J, Castell J, Bort R, Donato T, Ryan M, Corvi R, Keun H, Ebbels T, Athersuch T, Sansone SA, Rocca-Serra P, Stierum R, Jennings P, Pfaller W, Gmuender H, Vanhaecke T, Rogiers V MUTAT RES-FUND MOL M (659) 202-210.
[doi:10.1016/j.mrrev.2008.04.006]

Old donors in liver transplantation for chronic hepatitis C

Aguilera, V., Ponce, M., Berenguer, M., Moreno, R., Rayon, J. M., Sanjuan, F., Prieto, M., Mir, J. REV ESP ENFERM DIG (99) 581-587.

Lessons learned from anatomic variants of the hepatic artery in 1,081 transplanted livers

Lopez-Andujar, Rafael, Moya, Angel, Montalva, Eva, Berenguer, Marina, De Juan, Manuel, San Juan, Fernando, Pareja, Eugenia, Jose Vila, Juan, Orbis, Francisco, Prieto, Martin, Mir, Jose LIVER TRANSPLANT (13) 1401-1404.