Integrative Personal Omics Profiles in Glioblastoma Recurrence and Therapy Resistance

ERA PerMed Joint Transnational Call 2018
Investigador principal
Dr. Luis Martí-Bonmatí, IIS La Fe

PerProGlio Project aims to identify individual parameters that determine recurrence and therapy resistance in Glioblastoma (GBM) with possible therapeutic implications. The project will use a retrospective cohort of 100 patients with clinical metadata of GB, primary and recurrent samples, and will obtain abundance-based biomarkers associated with time-to recurrence and therapy resistance. In addition, a full NGS analysis will be performed to characterize recurrence in each individual patient and combine "OMICS" which clinical and imaging data. From these analyses, the project propose to identify personalized easy-to access biopsy markers. Finally, the project propose a multimodal monitoring, e.g. combining imaging data with molecular markers, that will allow to establish a molecular signature of GB recurrence which is particularly powerful for reliable prediction of GBM recurrence.