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Association between Intermittent Hypoxia and Later Respiratory Morbidity.
- Call
- NIH-R01-HL16-015
- Investigador principal
- Dr. Máximo Vento
- Role
- Consultant
- Year
- 2016
Longer term respiratory morbidity remains a major consequence of preterm birth. The hypotheses will be in Aims 1 and 2 that IH episodes at one week and one month of life are significantly associated with prolonged duration of hospitalization and respiratory support, as well as a high incidence of wheezing disorders by six months adjusted age. In Aim 3 that low serotonin levels are associated with a high incidence of IH and a prolonged recovery of respiratory effort after onset of desaturation. Finally, in Aim 4 a temporal relationship between IH episodes and markers of oxidative stress determined by urine and blood samples.